Chrna7 (GeneName), Neuronal acetylcholine receptor subunit alpha-7 (ProteinName), ACHA7_RAT.
Product Name:
Rat Chrna7/ Neuronal acetylcholine receptor subunit alpha-7 ELISA Kit
Cat.#:
E9618r
Brand:
EIAab®
Regulatory Status:
Alternative:
Acra7
Detection Method:
ELISA
Assay Type:
Sandwich
Detection Range:
0.156-10ng/mL
Sensitivity:
0.081ng/mL
Specificity:
Natural and recombinant rat Neuronal acetylcholine receptor subunit alpha-7
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Assay Procedure:
Research Area:
Neurosciences
- Data
- Citations
- Publication
- Sequence / 3D
- Feedback Wall (0)
Precision
Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Intra-Assay CV: ≤4.6%
Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.
Inter-Assay CV: ≤7.6%
Recovery
Recovery was determined by spiking various levels of Neuronal acetylcholine receptor subunit alpha-7 into serum and plasma.
|
Sample Type |
Average(%) |
Recovery Range(%) |
|
Serum |
96 |
90-102 |
|
Plasma |
98 |
92-104 |
Linearity
The linearity of the kit was assayed by testing samples spiked with appropriate concentration of Neuronal acetylcholine receptor subunit alpha-7 and their serial dilutions.
The results were demonstrated by the percentage of calculated concentration to the expected.
|
Sample |
1：2 |
1:4 |
1:8 |
1:16 |
|
serum(n=5) |
102-112% |
105-115% |
95-105% |
92-103% |
|
EDTA plasma(n=5) |
91-103% |
86-96% |
94-107% |
105-115% |
|
heparin plasma(n=5) |
101-110%
|
85-95% |
105-115% |
113-123% |
General Annotation
Sub Unit:
Homopentamer (By similarity). Interacts with RIC3; which is required for proper folding and assembly (PubMed:15927954, PubMed:16120769). Interacts with LYPD6 (By similarity). Interacts with the alpha-conotoxin RgIA (PubMed:25740413).
Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
Subcellular Location:
Cell junction
Synapse
Postsynaptic cell membrane
Multi-pass membrane protein
Cell membrane
Multi-pass membrane protein
Database link
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"APOE, ACT and CHRNA7 genes in the conversion from amnestic mild cognitive impairment to Alzheimer's disease."
[2].
"Association of the 5'-upstream regulatory region of the alpha7 nicotinic acetylcholine receptor subunit gene (CHRNA7) with schizophrenia."
[3].
"Alpha7 nicotinic acetylcholine receptor gene and reduced risk of Alzheimer's disease."
[4].
"Genetic variation in the alpha 7 nicotinic acetylcholine receptor is associated with delusional symptoms in Alzheimer's disease."
[5].
"[The transmission disequilibrium analysis between neuronal nicotinic acetylcholine receptor alpha 7 subunit gene polymorphisms and schizophrenia]."
Feedback Wall
Displaying result : 0
All customer
All customer
Default sort
Default sort
Newest first
Oldest first
No feedback yet, let's comment.
Message
Product Name *
Email *
Message: *
Inform
Size
Quantity
Price ($)
Subtotal 1 ($)
Subtotal 2:
$
Size
Quantity
Price ($)
Discount:
Please select at least one unit!
Do you want to be our agent and get a lower discount?
Please contact us:
Tel:
Fax:
Email:sales@eiaab.com
Please contact us:
Tel:
Fax:
Email:sales@eiaab.com