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CHRNA7 (GeneName), Neuronal acetylcholine receptor subunit alpha-7 (ProteinName), ACHA7_BOVIN.
Product Name:

Bovine CHRNA7/ Neuronal acetylcholine receptor subunit alpha-7 ELISA Kit

Cat.#:

E9618b

Brand:
EIAab®
Regulatory Status:
Detection Method:
ELISA
Specificity:
Natural and recombinant bovine Neuronal acetylcholine receptor subunit alpha-7
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Neurosciences
Bovine CHRNA7 ELISA Kit
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Bovine CHRNA7 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Homopentamer. Homooligomer of the short form gives rise to unfunctional channels, as does coexpression of both long and short forms of the receptor (PubMed:7620615). Interacts with RIC3; which is required for proper folding and assembly. Interacts with LYPD6 (By similarity). Interacts with the alpha-conotoxin RgIA.


Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.


Subcellular Location:
Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein


This product has not yet been referenced specifically in any publications.

[1].
"APOE, ACT and CHRNA7 genes in the conversion from amnestic mild cognitive impairment to Alzheimer's disease."

[2].
"Association of the 5'-upstream regulatory region of the alpha7 nicotinic acetylcholine receptor subunit gene (CHRNA7) with schizophrenia."

[3].
"Alpha7 nicotinic acetylcholine receptor gene and reduced risk of Alzheimer's disease."

[4].
"Genetic variation in the alpha 7 nicotinic acetylcholine receptor is associated with delusional symptoms in Alzheimer's disease."

[5].
"[The transmission disequilibrium analysis between neuronal nicotinic acetylcholine receptor alpha 7 subunit gene polymorphisms and schizophrenia]."
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