CHRNA7 (GeneName), Neuronal acetylcholine receptor subunit alpha-7 (ProteinName), ACHA7_BOVIN.
Product Name:
Bovine CHRNA7/ Neuronal acetylcholine receptor subunit alpha-7 ELISA Kit
Cat.#:
E9618b
Brand:
EIAab®
Regulatory Status:
Detection Method:
ELISA
Specificity:
Natural and recombinant bovine Neuronal acetylcholine receptor subunit alpha-7
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Neurosciences
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
Homopentamer. Homooligomer of the short form gives rise to unfunctional channels, as does coexpression of both long and short forms of the receptor (PubMed:7620615). Interacts with RIC3; which is required for proper folding and assembly. Interacts with LYPD6 (By similarity). Interacts with the alpha-conotoxin RgIA.
Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
Subcellular Location:
Cell junction
Synapse
Postsynaptic cell membrane
Multi-pass membrane protein
Cell membrane
Multi-pass membrane protein
Database link
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"APOE, ACT and CHRNA7 genes in the conversion from amnestic mild cognitive impairment to Alzheimer's disease."
[2].
"Association of the 5'-upstream regulatory region of the alpha7 nicotinic acetylcholine receptor subunit gene (CHRNA7) with schizophrenia."
[3].
"Alpha7 nicotinic acetylcholine receptor gene and reduced risk of Alzheimer's disease."
[4].
"Genetic variation in the alpha 7 nicotinic acetylcholine receptor is associated with delusional symptoms in Alzheimer's disease."
[5].
"[The transmission disequilibrium analysis between neuronal nicotinic acetylcholine receptor alpha 7 subunit gene polymorphisms and schizophrenia]."
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