CHRNA7 (GeneName), Neuronal acetylcholine receptor subunit alpha-7 (ProteinName), ACHA7_BOVIN.
Bovine CHRNA7/ Neuronal acetylcholine receptor subunit alpha-7 ELISA Kit
Natural and recombinant bovine Neuronal acetylcholine receptor subunit alpha-7
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Homopentamer. Homooligomer of the short form gives rise to unfunctional channels, as does coexpression of both long and short forms of the receptor (PubMed:7620615). Interacts with RIC3; which is required for proper folding and assembly. Interacts with LYPD6 (By similarity). Interacts with the alpha-conotoxin RgIA.
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein
MRGSLCLALA | ASILHVSLQG | EFQRKLYKDL | VKNYNPLERP | VANDSLPLTV |
YFSLSLLQIM | DVDEKNQVLT | TNIWLQMTWT | DHYLQWNASE | YPGVKTVRFP |
DGQIWKPDIL | LYNSADERFD | ATFHTNVLVN | SSGHCQYLPP | GIFKSSCYID |
VRWFPFDVQQ | CKLKFGSWSY | GGWSLDLQMQ | EADISGYIPN | GEWDLVGVLG |
KRSEKFYECC | KEPYPDVTFT | VSIRRRTLYY | GLNLLIPCVL | ISALALLVFL |
LPADSGEKIS | LGITVLLSLT | VFMLLVAEIM | PATSDSVPLI | AQYFASTMII |
VGLSVVVTVI | VLQYHHHDPD | GGKMPKWTRV | VLLNWCAWFL | RMKRPGEDKV |
RPACQHNERR | CSLASVEMSA | VAGPPATNGN | LLYIGFRGLD | TMHCAPTPDS |
GVVCGRVACS | PTHDEHLLHA | GQPSEGDPDL | AKILEEVRYI | AHRFRCQDES |
EAVCSEWKFA | ACVVDRLCLM | AFSVFTILCT | IGILMSAPNF | VEAVSKDFA
This product has not yet been referenced specifically in any publications.
"APOE, ACT and CHRNA7 genes in the conversion from amnestic mild cognitive impairment to Alzheimer's disease."
"Association of the 5'-upstream regulatory region of the alpha7 nicotinic acetylcholine receptor subunit gene (CHRNA7) with schizophrenia."
"Alpha7 nicotinic acetylcholine receptor gene and reduced risk of Alzheimer's disease."
"Genetic variation in the alpha 7 nicotinic acetylcholine receptor is associated with delusional symptoms in Alzheimer's disease."
"[The transmission disequilibrium analysis between neuronal nicotinic acetylcholine receptor alpha 7 subunit gene polymorphisms and schizophrenia]."
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