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CHRNA6 (GeneName), Neuronal acetylcholine receptor subunit alpha-6 (ProteinName), ACHA6_CHICK.

Product Name:

Chicken CHRNA6/ Neuronal acetylcholine receptor subunit alpha-6 ELISA Kit

Cat.#:

Brand:

EIAab^®

Regulatory Status:

RUO

Detection Method:

ELISA

Specificity:

Natural and recombinant chicken Neuronal acetylcholine receptor subunit alpha-6

Sample Type:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Sample Data:

Research Area:

Neurosciences

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Chicken CHRNA6 ELISA Kit

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Product Datasheets

Data
Citations
Publication
Sequence / 3D
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General Annotation

Sub Unit:

Neuronal AChR seems to be composed of two different type of subunits: alpha and non-alpha (also called beta). A functional receptor seems to consist of two alpha-chains and three non-alpha chains.

Function:

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Subcellular Location:

Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein

Database link

UniGene:

Gga.340

STRING:

9031.ENSGALP00000036997

KEGG:

gga:396321

Pfam:

PF02931

Uniprot:

P49581

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Sequence length:

494

Sequence:

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450:

494:

ETKEVEDDWK | YVAMVIDRVF | LWVFIILCVF | GTAGLFIQPL | IADT

3D Structure:

Predicted Epitope:

Valid Sequence:

This product has not yet been referenced specifically in any publications.

[1].

"Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits."

(PMID: 8906617)

[2].

"Functional interaction between Lypd6 and nicotinic acetylcholine receptors."

(PMID: 27344019)

[3].

"Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior."

(PMID: 20418888)

[4].

"Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans."

(PMID: 20584212)

[5].

"A large-scale candidate gene association study of age at menarche and age at natural menopause."

(PMID: 20734064)

[6].

"Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the Fagerstr?m test for nicotine dependence."

(PMID: 20736995)

[7].

"Prenatal exposure to maternal cigarette smoking interacts with a polymorphism in the alpha6 nicotinic acetylcholine receptor gene to influence drug use and striatum volume in adolescence."

(PMID: 20029407)

[8].

"Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment."

(PMID: 19086053)

[9].

"Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis."

(PMID: 19156168)

[10].

"Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes."

(PMID: 19259974)

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