Chrna5 (GeneName), Neuronal acetylcholine receptor subunit alpha-5 (ProteinName), ACHA5_RAT.
Product Name:
Rat Chrna5/ Neuronal acetylcholine receptor subunit alpha-5 ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
Acra5
Detection Method:
ELISA
Specificity:
Natural and recombinant rat Neuronal acetylcholine receptor subunit alpha-5
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Neurosciences
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
Neuronal AChR seems to be composed of two different types of subunits: alpha and non-alpha (beta). Interacts with LYPD6.
Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular Location:
Cell junction
Synapse
Postsynaptic cell membrane
Multi-pass membrane protein
Cell membrane
Multi-pass membrane protein
This product has not yet been referenced specifically in any publications.
[1].
"Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans."
[2].
"Smoking cessation and variations in nicotinic acetylcholine receptor subunits alpha-5, alpha-3, and beta-4 genes."
[3].
"Transcription deregulation at the 15q25 locus in association with lung adenocarcinoma risk."
[4].
"Association of genes coding for the alpha-4, alpha-5, beta-2 and beta-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence."
[5].
"Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function."
[6].
"Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1."
[7].
"A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25."
[8].
"A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence."
[10].
"Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smoking."
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