Home > ELISA Kit > Rat Chrna5 ELISA Kit

Chrna5 (GeneName), Neuronal acetylcholine receptor subunit alpha-5 (ProteinName), ACHA5_RAT.

Product Name:

Rat Chrna5/ Neuronal acetylcholine receptor subunit alpha-5 ELISA Kit

Cat.#:

Brand:

EIAab^®

Regulatory Status:

RUO

Alternative:

Acra5

Detection Method:

ELISA

Specificity:

Natural and recombinant rat Neuronal acetylcholine receptor subunit alpha-5

Sample Type:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Sample Data:

Research Area:

Neurosciences

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Rat Chrna5 ELISA Kit

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Product Datasheets

Data
Citations
Publication
Sequence / 3D
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General Annotation

Sub Unit:

Neuronal AChR seems to be composed of two different types of subunits: alpha and non-alpha (beta). Interacts with LYPD6.

Function:

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Subcellular Location:

Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein

Database link

UniGene:

Rn.40125

STRING:

10116.ENSRNOP00000062227

Pfam:

PF02931

Uniprot:

P20420

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Sequence length:

452

Sequence:

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452:

3D Structure:

Predicted Epitope:

Valid Sequence:

This product has not yet been referenced specifically in any publications.

[1].

"Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans."

(PMID: 19859904)

[2].

"Smoking cessation and variations in nicotinic acetylcholine receptor subunits alpha-5, alpha-3, and beta-4 genes."

(PMID: 18996504)

[3].

"Transcription deregulation at the 15q25 locus in association with lung adenocarcinoma risk."

(PMID: 19223495)

[4].

"Association of genes coding for the alpha-4, alpha-5, beta-2 and beta-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence."

(PMID: 19482438)

[5].

"Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function."

(PMID: 17559419)

[6].

"Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1."

(PMID: 18385676)

[7].

"A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25."

(PMID: 18385738)

[8].

"A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence."

(PMID: 18519132)

[9].

"Variants in nicotinic receptors and risk for nicotine dependence."

(PMID: 18519524)

[10].

"Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smoking."

(PMID: 18783506)

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