CHRNA5 (GeneName), Neuronal acetylcholine receptor subunit alpha-5 (ProteinName), ACHA5_HUMAN.
Human CHRNA5/ Neuronal acetylcholine receptor subunit alpha-5 ELISA Kit
Natural and recombinant human Neuronal acetylcholine receptor subunit alpha-5
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Neuronal AChR seems to be composed of two different type of subunits: alpha and non-alpha (beta). Interacts with LYPD6 (PubMed:27344019).
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein
MAARGSGPRA | LRLLLLVQLV | AGRCGLAGAA | GGAQRGLSEP | SSIAKHEDSL |
LKDLFQDYER | WVRPVEHLND | KIKIKFGLAI | SQLVDVDEKN | QLMTTNVWLK |
QEWIDVKLRW | NPDDYGGIKV | IRVPSDSVWT | PDIVLFDNAD | GRFEGTSTKT |
VIRYNGTVTW | TPPANYKSSC | TIDVTFFPFD | LQNCSMKFGS | WTYDGSQVDI |
ILEDQDVDKR | DFFDNGEWEI | VSATGSKGNR | TDSCCWYPYV | TYSFVIKRLP |
LFYTLFLIIP | CIGLSFLTVL | VFYLPSNEGE | KICLCTSVLV | SLTVFLLVIE |
EIIPSSSKVI | PLIGEYLVFT | MIFVTLSIMV | TVFAINIHHR | SSSTHNAMAP |
LVRKIFLHTL | PKLLCMRSHV | DRYFTQKEET | ESGSGPKSSR | NTLEAALDSI |
RYITRHIMKE | NDVREVVEDW | KFIAQVLDRM | FLWTFLFVSI | VGSLGLFVPV |
IYKWANILIP | VHIGNANK
This product has not yet been referenced specifically in any publications.
"Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans."
"Smoking cessation and variations in nicotinic acetylcholine receptor subunits alpha-5, alpha-3, and beta-4 genes."
"Transcription deregulation at the 15q25 locus in association with lung adenocarcinoma risk."
"Association of genes coding for the alpha-4, alpha-5, beta-2 and beta-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence."
"Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function."
"Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1."
"A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25."
"A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence."
"Variants in nicotinic receptors and risk for nicotine dependence."
"Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smoking."
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