Home > ELISA Kit > Rat Chrna4 ELISA Kit

Chrna4 (GeneName), Neuronal acetylcholine receptor subunit alpha-4 (ProteinName), ACHA4_RAT.

Product Name:

Rat Chrna4/ Neuronal acetylcholine receptor subunit alpha-4 ELISA Kit

Cat.#:

E1913r

Brand:

EIAab^®

Regulatory Status:

RUO

Alternative:

Acra4

Detection Method:

ELISA

Assay Type:

Sandwich

Detection Range:

78-5000pg/mL

Sensitivity:

26pg/mL

Specificity:

Natural and recombinant rat Neuronal acetylcholine receptor subunit alpha-4

Sample Type:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Sample Data:

Assay Procedure:

Research Area:

Neurosciences

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Rat Chrna4 ELISA Kit

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Product Datasheets

Instruction:

MSDS:

Data
Citations
Publication
Sequence / 3D
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General Annotation

Sub Unit:

Neuronal AChR is composed of two different types of subunits: alpha and beta. Alpha-4 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors, complexes with beta-2 may be heteropentamers. Interacts with RIC3; which is required for proper folding and assembly. Interacts with LYPD6.

Function:

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.

Subcellular Location:

Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein Cell membrane Lipid-anchor

Database link

UniGene:

Rn.9697

STRING:

10116.ENSRNOP00000009041

KEGG:

rno:25590

Pfam:

PF02931

Uniprot:

P09483

Related Product

Human CHRNA4 ELISA Kit

Mouse Chrna4 ELISA Kit

Chicken CHRNA4 ELISA Kit

Human CHRNA4 CLIA Kit

Mouse Chrna4 CLIA Kit

Sequence length:

630

Sequence:

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630:

VIDRIFLWMF | IIVCLLGTVG | LFLPPWLAAC |

3D Structure:

Predicted Epitope:

Valid Sequence:

This product has not yet been referenced specifically in any publications.

[1].

"CHRNA2 mutations are rare in the NFLE population: evaluation of a large cohort of Italian patients."

(PMID: 18226955)

[2].

"A novel mutation of the nicotinic acetylcholine receptor gene CHRNA4 in sporadic nocturnal frontal lobe epilepsy."

(PMID: 19058950)

[3].

"Association of genes coding for the alpha-4, alpha-5, beta-2 and beta-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence."

(PMID: 19482438)

[4].

"Rare missense variants of neuronal nicotinic acetylcholine receptor altering receptor function are associated with sporadic amyotrophic lateral sclerosis."

(PMID: 19628475)

[5].

"Association of nAChR gene haplotypes with heavy alcohol use and body mass."

(PMID: 19698703)

[6].

"Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene."

(PMID: 19693267)

[7].

"The 1674+11C>T polymorphism of CHRNA4 is associated with juvenile myoclonic epilepsy."

(PMID: 19577488)

[8].

"Association of nicotinic acetylcholine receptor subunit alpha 4 polymorphisms with nicotine dependence in 5500 Germans."

(PMID: 19290018)

[9].

"Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function."

(PMID: 17559419)

[10].

"Alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes are not associated with methamphetamine-use disorder in the Japanese population."

(PMID: 18991851)

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