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Home  >  ELISA Kit  >  Rat Chrna4 ELISA Kit
Chrna4 (GeneName), Neuronal acetylcholine receptor subunit alpha-4 (ProteinName), ACHA4_RAT.
Product Name:

Rat Chrna4/ Neuronal acetylcholine receptor subunit alpha-4 ELISA Kit

Cat.#:

E1913r

Brand:
EIAab®
Regulatory Status:
Alternative:

Acra4

Detection Method:
ELISA
Assay Type:
Sandwich
Detection Range:
78-5000pg/mL
Sensitivity:
26pg/mL
Specificity:
Natural and recombinant rat Neuronal acetylcholine receptor subunit alpha-4
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Assay Procedure:
Assay Procedure
Research Area:
Neurosciences
Rat Chrna4 ELISA Kit
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Rat Chrna4 ELISA Kit
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Product Datasheets
Instruction: Down Instruction
MSDS: MSDS


General Annotation


Sub Unit:
Neuronal AChR is composed of two different types of subunits: alpha and beta. Alpha-4 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors, complexes with beta-2 may be heteropentamers. Interacts with RIC3; which is required for proper folding and assembly. Interacts with LYPD6.


Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.


Subcellular Location:
Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein Cell membrane Lipid-anchor


This product has not yet been referenced specifically in any publications.

[1].
"CHRNA2 mutations are rare in the NFLE population: evaluation of a large cohort of Italian patients."

[2].
"A novel mutation of the nicotinic acetylcholine receptor gene CHRNA4 in sporadic nocturnal frontal lobe epilepsy."

[3].
"Association of genes coding for the alpha-4, alpha-5, beta-2 and beta-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence."

[4].
"Rare missense variants of neuronal nicotinic acetylcholine receptor altering receptor function are associated with sporadic amyotrophic lateral sclerosis."

[5].
"Association of nAChR gene haplotypes with heavy alcohol use and body mass."

[6].
"Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene."

[7].
"The 1674+11C>T polymorphism of CHRNA4 is associated with juvenile myoclonic epilepsy."

[8].
"Association of nicotinic acetylcholine receptor subunit alpha 4 polymorphisms with nicotine dependence in 5500 Germans."

[9].
"Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function."

[10].
"Alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes are not associated with methamphetamine-use disorder in the Japanese population."
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