CHRNA4 (GeneName), Neuronal acetylcholine receptor subunit alpha-4 (ProteinName), ACHA4_HUMAN.
Human CHRNA4/ Neuronal acetylcholine receptor subunit alpha-4 ELISA Kit
Natural and recombinant human Neuronal acetylcholine receptor subunit alpha-4
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Neuronal AChR is composed of two different types of subunits: alpha and beta. Alpha-4 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors, complexes with beta-2 may be heteropentamers (PubMed:22361591). Interacts with RIC3; which is required for proper folding and assembly (PubMed:16120769). Interacts with LYPD6 (PubMed:27344019).
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.
Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein Cell membrane Lipid-anchor
MELGGPGAPR | LLPPLLLLLG | TGLLRASSHV | ETRAHAEERL | LKKLFSGYNK |
WSRPVANISD | VVLVRFGLSI | AQLIDVDEKN | QMMTTNVWVK | QEWHDYKLRW |
DPADYENVTS | IRIPSELIWR | PDIVLYNNAD | GDFAVTHLTK | AHLFHDGRVQ |
WTPPAIYKSS | CSIDVTFFPF | DQQNCTMKFG | SWTYDKAKID | LVNMHSRVDQ |
LDFWESGEWV | IVDAVGTYNT | RKYECCAEIY | PDITYAFVIR | RLPLFYTINL |
IIPCLLISCL | TVLVFYLPSE | CGEKITLCIS | VLLSLTVFLL | LITEIIPSTS |
LVIPLIGEYL | LFTMIFVTLS | IVITVFVLNV | HHRSPRTHTM | PTWVRRVFLD |
IVPRLLLMKR | PSVVKDNCRR | LIESMHKMAS | APRFWPEPEG | EPPATSGTQS |
LHPPSPSFCV | PLDVPAEPGP | SCKSPSDQLP | PQQPLEAEKA | SPHPSPGPCR |
PPHGTQAPGL | AKARSLSVQH | MSSPGEAVEG | GVRCRSRSIQ | YCVPRDDAAP |
EADGQAAGAL | ASRNTHSAEL | PPPDQPSPCK | CTCKKEPSSV | SPSATVKTRS |
TKAPPPHLPL | SPALTRAVEG | VQYIADHLKA | EDTDFSVKED | WKYVAMVIDR |
IFLWMFIIVC | LLGTVGLFLP | PWLAGMI
This product has not yet been referenced specifically in any publications.
"CHRNA2 mutations are rare in the NFLE population: evaluation of a large cohort of Italian patients."
"A novel mutation of the nicotinic acetylcholine receptor gene CHRNA4 in sporadic nocturnal frontal lobe epilepsy."
"Association of genes coding for the alpha-4, alpha-5, beta-2 and beta-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence."
"Rare missense variants of neuronal nicotinic acetylcholine receptor altering receptor function are associated with sporadic amyotrophic lateral sclerosis."
"Association of nAChR gene haplotypes with heavy alcohol use and body mass."
"Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene."
"The 1674+11C>T polymorphism of CHRNA4 is associated with juvenile myoclonic epilepsy."
"Association of nicotinic acetylcholine receptor subunit alpha 4 polymorphisms with nicotine dependence in 5500 Germans."
"Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function."
"Alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes are not associated with methamphetamine-use disorder in the Japanese population."
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