CHRNA4 (GeneName), Neuronal acetylcholine receptor subunit alpha-4 (ProteinName), ACHA4_CHICK.
Chicken CHRNA4/ Neuronal acetylcholine receptor subunit alpha-4 ELISA Kit
Natural and recombinant chicken Neuronal acetylcholine receptor subunit alpha-4
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Neuronal AChR seems to be composed of two different type of subunits: alpha and non-alpha (also called beta). A functional receptor seems to consist of two alpha-chains and three non-alpha chains.
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein Cell membrane Lipid-anchor
MGFLVSKGNL | LLLLCASIFP | AFGHVETRAH | AEERLLKKLF | SGYNKWSRPV |
ANISDVVLVR | FGLSIAQLID | VDEKNQMMTT | NVWVKQEWHD | YKLRWDPQEY |
ENVTSIRIPS | ELIWRPDIVL | YNNADGDFAV | THLTKAHLFY | DGRIKWMPPA |
IYKSSCSIDV | TFFPFDQQNC | KMKFGSWTYD | KAKIDLVSMH | SHVDQLDYWE |
SGEWVIINAV | GNYNSKKYEC | CTEIYPDITY | SFIIRRLPLF | YTINLIIPCL |
LISCLTVLVF | YLPSECGEKI | TLCISVLLSL | TVFLLLITEI | IPSTSLVIPL |
IGEYLLFTMI | FVTLSIIITV | FVLNVHHRSP | RTHTMPDWVR | RVFLDIVPRL |
LFMKRPSTVK | DNCKKLIESM | HKLTNSPRLW | SETDMEPNFT | TSSSPSPQSN |
EPSPTSSFCA | HLEEPAKPMC | KSPSGQYSML | HPEPPQVTCS | SPKPSCHPLS |
DTQTTSISKG | RSLSVQQMYS | PNKTEEGSIR | CRSRSIQYCY | LQEDSSQTNG |
HSSASPASQR | CHLNEEQPQH | KPHQCKCKCR | KGEAAGTPTQ | GSKSHSNKGE |
HLVLMSPALK | LAVEGVHYIA | DHLRAEDADF | SVKEDWKYVA | MVIDRIFLWM |
FIIVCLLGTV | GLFLPPWLAG | MI
This product has not yet been referenced specifically in any publications.
"CHRNA2 mutations are rare in the NFLE population: evaluation of a large cohort of Italian patients."
"A novel mutation of the nicotinic acetylcholine receptor gene CHRNA4 in sporadic nocturnal frontal lobe epilepsy."
"Association of genes coding for the alpha-4, alpha-5, beta-2 and beta-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence."
"Rare missense variants of neuronal nicotinic acetylcholine receptor altering receptor function are associated with sporadic amyotrophic lateral sclerosis."
"Association of nAChR gene haplotypes with heavy alcohol use and body mass."
"Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene."
"The 1674+11C>T polymorphism of CHRNA4 is associated with juvenile myoclonic epilepsy."
"Association of nicotinic acetylcholine receptor subunit alpha 4 polymorphisms with nicotine dependence in 5500 Germans."
"Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function."
"Alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes are not associated with methamphetamine-use disorder in the Japanese population."
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