Chrna3 (GeneName), Neuronal acetylcholine receptor subunit alpha-3 (ProteinName), ACHA3_RAT.
Product Name:
Rat Chrna3/ Neuronal acetylcholine receptor subunit alpha-3 ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
Acra3
Detection Method:
ELISA
Specificity:
Natural and recombinant rat Neuronal acetylcholine receptor subunit alpha-3
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Neurosciences
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
Neuronal AChR is composed of two different types of subunits: alpha and beta. Alpha-3 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly. Interacts with LYPD6.
Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular Location:
Cell junction
Synapse
Postsynaptic cell membrane
Multi-pass membrane protein
Cell membrane
Multi-pass membrane protein
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"Sensorimotor gating is associated with CHRNA3 polymorphisms in schizophrenia and healthy volunteers."
[2].
"Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans."
[3].
"Rare missense variants of neuronal nicotinic acetylcholine receptor altering receptor function are associated with sporadic amyotrophic lateral sclerosis."
[4].
"Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1."
[5].
"A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25."
[6].
"A variant associated with nicotine dependence, lung cancer and peripheral arterial disease."
[7].
"Association of novel and established polymorphisms in neuronal nicotinic acetylcholine receptors with sporadic Alzheimer's disease."
[8].
"The structures of the human neuronal nicotinic acetylcholine receptor beta2- and alpha3-subunit genes (CHRNB2 and CHRNA3)."
[10].
"Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function."
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