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Home  >  ELISA Kit  >  Rat Chrna3 ELISA Kit
Chrna3 (GeneName), Neuronal acetylcholine receptor subunit alpha-3 (ProteinName), ACHA3_RAT.
Product Name:

Rat Chrna3/ Neuronal acetylcholine receptor subunit alpha-3 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Acra3

Detection Method:
ELISA
Specificity:
Natural and recombinant rat Neuronal acetylcholine receptor subunit alpha-3
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Neurosciences
Rat Chrna3 ELISA Kit
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Rat Chrna3 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Neuronal AChR is composed of two different types of subunits: alpha and beta. Alpha-3 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly. Interacts with LYPD6.


Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.


Subcellular Location:
Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein


This product has not yet been referenced specifically in any publications.

[1].
"Sensorimotor gating is associated with CHRNA3 polymorphisms in schizophrenia and healthy volunteers."

[2].
"Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans."

[3].
"Rare missense variants of neuronal nicotinic acetylcholine receptor altering receptor function are associated with sporadic amyotrophic lateral sclerosis."

[4].
"Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1."

[5].
"A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25."

[6].
"A variant associated with nicotine dependence, lung cancer and peripheral arterial disease."

[7].
"Association of novel and established polymorphisms in neuronal nicotinic acetylcholine receptors with sporadic Alzheimer's disease."

[8].
"The structures of the human neuronal nicotinic acetylcholine receptor beta2- and alpha3-subunit genes (CHRNB2 and CHRNA3)."

[9].
"Functional interaction between Lypd6 and nicotinic acetylcholine receptors."

[10].
"Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function."
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