CHRNA3 (GeneName), Neuronal acetylcholine receptor subunit alpha-3 (ProteinName), ACHA3_HUMAN.
Human CHRNA3/ Neuronal acetylcholine receptor subunit alpha-3 ELISA Kit
Natural and recombinant human Neuronal acetylcholine receptor subunit alpha-3
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Neuronal AChR is composed of two different types of subunits: alpha and beta. Alpha-3 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly (PubMed:16120769). Interacts with LYPD6 (PubMed:27344019).
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein
MGSGPLSLPL | ALSPPRLLLL | LLLSLLPVAR | ASEAEHRLFE | RLFEDYNEII |
RPVANVSDPV | IIHFEVSMSQ | LVKVDEVNQI | METNLWLKQI | WNDYKLKWNP |
SDYGGAEFMR | VPAQKIWKPD | IVLYNNAVGD | FQVDDKTKAL | LKYTGEVTWI |
PPAIFKSSCK | IDVTYFPFDY | QNCTMKFGSW | SYDKAKIDLV | LIGSSMNLKD |
YWESGEWAII | KAPGYKHDIK | YNCCEEIYPD | ITYSLYIRRL | PLFYTINLII |
PCLLISFLTV | LVFYLPSDCG | EKVTLCISVL | LSLTVFLLVI | TETIPSTSLV |
IPLIGEYLLF | TMIFVTLSIV | ITVFVLNVHY | RTPTTHTMPS | WVKTVFLNLL |
PRVMFMTRPT | SNEGNAQKPR | PLYGAELSNL | NCFSRAESKG | CKEGYPCQDG |
MCGYCHHRRI | KISNFSANLT | RSSSSESVDA | VLSLSALSPE | IKEAIQSVKY |
IAENMKAQNE | AKEIQDDWKY | VAMVIDRIFL | WVFTLVCILG | TAGLFLQPLM |
This product has not yet been referenced specifically in any publications.
"Sensorimotor gating is associated with CHRNA3 polymorphisms in schizophrenia and healthy volunteers."
"Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans."
"Rare missense variants of neuronal nicotinic acetylcholine receptor altering receptor function are associated with sporadic amyotrophic lateral sclerosis."
"Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1."
"A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25."
"A variant associated with nicotine dependence, lung cancer and peripheral arterial disease."
"Association of novel and established polymorphisms in neuronal nicotinic acetylcholine receptors with sporadic Alzheimer's disease."
"The structures of the human neuronal nicotinic acetylcholine receptor beta2- and alpha3-subunit genes (CHRNB2 and CHRNA3)."
"Functional interaction between Lypd6 and nicotinic acetylcholine receptors."
"Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function."
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