Chrna2 (GeneName), Neuronal acetylcholine receptor subunit alpha-2 (ProteinName), ACHA2_RAT.
Rat Chrna2/ Neuronal acetylcholine receptor subunit alpha-2 ELISA Kit
Natural and recombinant rat Neuronal acetylcholine receptor subunit alpha-2
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Neuronal AChR seems to be composed of two different types of subunits: alpha and non-alpha (beta). Alpha-2 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors. The alpha-2:beta-2 nAChR complex is proposed to be a heteropentamer with two subtypes: LS (low agonist sensitivity) with a (alpha-2)3:(beta-2)2 and HS (high agonist sensitivity) with a (alpha-2)2:(beta-2)3 stoichiometry; the subtypes differ in their subunit binding interfaces which are involved in ligand binding.
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein
MTLSHSALQF | WTHLYLWCLL | LVPAVLTQQG | SHTHAEDRLF | KHLFGGYNRW |
ARPVPNTSDV | VIVRFGLSIA | QLIDVDEKNQ | MMTTNVWLKQ | EWNDYKLRWD |
PAEFGNVTSL | RVPSEMIWIP | DIVLYNNADG | EFAVTHMTKA | HLFFTGTVHW |
VPPAIYKSSC | SIDVTFFPFD | QQNCKMKFGS | WTYDKAKIDL | EQMERTVDLK |
DYWESGEWAI | INATGTYNSK | KYDCCAEIYP | DVTYYFVIRR | LPLFYTINLI |
IPCLLISCLT | VLVFYLPSEC | GEKITLCISV | LLSLTVFLLL | ITEIIPSTSL |
VIPLIGEYLL | FTMIFVTLSI | VITVFVLNVH | HRSPSTHNMP | NWVRVALLGR |
VPRWLMMNRP | LPPMELHGSP | DLKLSPSYHW | LETNMDAGER | EETEEEEEEE |
DENICVCAGL | PDSSMGVLYG | HGGLHLRAME | PETKTPSQAS | EILLSPQIQK |
ALEGVHYIAD | RLRSEDADSS | VKEDWKYVAM | VVDRIFLWLF | IIVCFLGTIG |
LFLPPFLAGM | I
This product has not yet been referenced specifically in any publications.
"CHRNA2 mutations are rare in the NFLE population: evaluation of a large cohort of Italian patients."
"A novel mutation of the nicotinic acetylcholine receptor gene CHRNA4 in sporadic nocturnal frontal lobe epilepsy."
"Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function."
"A major role of the nicotinic acetylcholine receptor gene CHRNA2 in autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is unlikely."
"Increased sensitivity of the neuronal nicotinic receptor alpha 2 subunit causes familial epilepsy with nocturnal wandering and ictal fear."
"Crystal structure of a human neuronal nAChR extracellular domain in pentameric assembly: Ligand-bound α2 homopentamer."
"Mutation of CHRNA2 in a family with benign familial infantile seizures: Potential role of nicotinic acetylcholine receptor in various phenotypes of epilepsy."
"Human variation in alcohol response is influenced by variation in neuronal signaling genes."
"Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans."
"A large-scale candidate gene association study of age at menarche and age at natural menopause."
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