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Chrna2 (GeneName), Neuronal acetylcholine receptor subunit alpha-2 (ProteinName), ACHA2_MOUSE.
Product Name:

Mouse Chrna2/ Neuronal acetylcholine receptor subunit alpha-2 ELISA Kit

Cat.#:

E1926m

Brand:
EIAab®
Regulatory Status:
Detection Method:
ELISA
Assay Type:
Sandwich
Detection Range:
0.78-50ng/mL
Sensitivity:
0.399ng/mL
Specificity:
Natural and recombinant mouse Neuronal acetylcholine receptor subunit alpha-2
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Assay Procedure:
Assay Procedure
Research Area:
Neurosciences
Mouse Chrna2 ELISA Kit
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Mouse Chrna2 ELISA Kit
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Product Datasheets
Instruction: Down Instruction
MSDS: MSDS


General Annotation


Sub Unit:
Neuronal AChR seems to be composed of two different types of subunits: alpha and non-alpha (beta). Alpha-2 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors. The alpha-2:beta-2 nAChR complex is proposed to be a heteropentamer with two subtypes: LS (low agonist sensitivity) with a (alpha-2)3:(beta-2)2 and HS (high agonist sensitivity) with a (alpha-2)2:(beta-2)3 stoichiometry; the subtypes differ in their subunit binding interfaces which are involved in ligand binding.


Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.


Subcellular Location:
Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein


This product has not yet been referenced specifically in any publications.

[1].
"CHRNA2 mutations are rare in the NFLE population: evaluation of a large cohort of Italian patients."

[2].
"A novel mutation of the nicotinic acetylcholine receptor gene CHRNA4 in sporadic nocturnal frontal lobe epilepsy."

[3].
"Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function."

[4].
"A major role of the nicotinic acetylcholine receptor gene CHRNA2 in autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is unlikely."

[5].
"Increased sensitivity of the neuronal nicotinic receptor alpha 2 subunit causes familial epilepsy with nocturnal wandering and ictal fear."

[6].
"Crystal structure of a human neuronal nAChR extracellular domain in pentameric assembly: Ligand-bound α2 homopentamer."

[7].
"Mutation of CHRNA2 in a family with benign familial infantile seizures: Potential role of nicotinic acetylcholine receptor in various phenotypes of epilepsy."

[8].
"Human variation in alcohol response is influenced by variation in neuronal signaling genes."

[9].
"Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans."

[10].
"A large-scale candidate gene association study of age at menarche and age at natural menopause."
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