Chrna10 (GeneName), Neuronal acetylcholine receptor subunit alpha-10 (ProteinName), ACH10_RAT.
Rat Chrna10/ Neuronal acetylcholine receptor subunit alpha-10 ELISA Kit
Nicotinic acetylcholine receptor subunit alpha-10, NACHR alpha-10
Natural and recombinant rat Neuronal acetylcholine receptor subunit alpha-10
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Forms heterooligomeric channels in conjunction with CHRNA9. The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 heterooligomers. Interacts with the conotoxin GeXXA (PubMed:26395518). Interacts with the alpha-conotoxin RgIA (PubMed:25740413).
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this leads to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.
Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein
MGTRSHYLDL | GFLLLLFLPA | ECLGAEGRLA | HKLFRDLFAN | YTSALRPVAD |
TDQTLNVTLE | VTLSQIIDMD | ERNQVLTLYL | WIRQEWTDAY | LHWDPKAYGD |
LDAIRIPSRL | VWRPDIVLYN | KADTQPPASA | STNVVVRHDG | AVRWDAPAIT |
RSSCRVDVSA | FPFDAQRCGL | TFGSWTHGGH | QLDVRPRGTS | ASLADFVENV |
EWRVLGMPAR | RRVLTYGCCS | EPYPDVTFTL | LLRRRAAAYV | CNLLLPCVFI |
SLLAPLAFHL | PADSGEKVSL | GVTVLLALTV | FQLILAESMP | PAESVPLIGK |
YYMATMTMVT | FSTALTILIM | NLHYCGPNAH | PVPAWARVLL | LGHLAKGLCV |
RERGEPCGQS | KPLESAPSLQ | PPPASPAGPC | HEPRCLCHQE | ALLHHIASIA |
STFRSHRAAQ | RRHEDWKRLA | RVMDRFFLGI | FFCMALVMSL | IVLVQAL
This product has not yet been referenced specifically in any publications.
"Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function."
"Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10)."
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."
"Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans."
"A large-scale candidate gene association study of age at menarche and age at natural menopause."
"Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis."
"Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes."
"No evidence for association between 19 cholinergic genes and bipolar disorder."
"Characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) and alpha (alpha) 10 (CHRNA10) in lymphocytes."
"A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit."
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