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Chrna10 (GeneName), Neuronal acetylcholine receptor subunit alpha-10 (ProteinName), ACH10_RAT.
Product Name:

Rat Chrna10/ Neuronal acetylcholine receptor subunit alpha-10 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Nicotinic acetylcholine receptor subunit alpha-10, NACHR alpha-10

Detection Method:
ELISA
Specificity:
Natural and recombinant rat Neuronal acetylcholine receptor subunit alpha-10
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Neurosciences
Rat Chrna10 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Forms heterooligomeric channels in conjunction with CHRNA9. The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 heterooligomers. Interacts with the conotoxin GeXXA (PubMed:26395518). Interacts with the alpha-conotoxin RgIA (PubMed:25740413).


Function:
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this leads to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.


Subcellular Location:
Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein


This product has not yet been referenced specifically in any publications.

[1].
"Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function."

[2].
"Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10)."

[3].
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."

[4].
"Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans."

[5].
"A large-scale candidate gene association study of age at menarche and age at natural menopause."

[6].
"Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis."

[7].
"Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes."

[8].
"No evidence for association between 19 cholinergic genes and bipolar disorder."

[9].
"Characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) and alpha (alpha) 10 (CHRNA10) in lymphocytes."

[10].
"A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit."
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