ACHE (GeneName), Acetylcholinesterase (ProteinName), ACES_BOVIN.
Bovine ACHE/ Acetylcholinesterase ELISA Kit
Natural and recombinant bovine Acetylcholinesterase
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with PRIMA1. The interaction with PRIMA1 is required to anchor it to the basal lamina of cells and organize into tetramers (By similarity). Isoform H generates GPI-anchored dimers; disulfide linked. Isoform T generates multiple structures, ranging from monomers and dimers to collagen-tailed and hydrophobic-tailed forms, in which catalytic tetramers are associated with anchoring proteins that attach them to the basal lamina or to cell membranes. In the collagen-tailed forms, isoform T subunits are associated with a specific collagen, COLQ, which triggers the formation of isoform T tetramers, from monomers and dimers.
Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
Isoform H Cell membrane Lipid-anchor GPI-anchor Extracellular side
MRPPWCPLHT | PSLTPPLLLL | LFLIGGGAEA | EGPEDPELLV | MVRGGRLRGL |
RLMAPRGPVS | AFLGIPFAEP | PVGPRRFLPP | EPKRPWPGVL | NATAFQSVCY |
QYVDTLYPGF | EGTEMWNPNR | ELSEDCLYLN | VWTPYPRPSS | PTPVLVWIYG |
GGFYSGASSL | DVYDGRFLTQ | AEGTVLVSMN | YRVGAFGFLA | LPGSREAPGN |
VGLLDQRLAL | QWVQENVAAF | GGDPTSVTLF | GESAGAASVG | MHLLSPPSRG |
LFHRAVLQSG | APNGPWATVG | VGEARRRATL | LARLVGCPPG | GAGGNDTELV |
ACLRARPAQD | LVDHEWRVLP | QESVFRFSFV | PVVDGDFLSD | TPEALINAGD |
FHGLQVLVGV | VKDEGSYFLV | YGAPGFSKDN | ESLISRAQFL | AGVRVGVPQA |
SDLAAEAVVL | HYTDWLHPED | PARLREALSD | VVGDHNVVCP | VAQLAGRLAA |
QGARVYAYIF | EHRASTLSWP | LWMGVPHGYE | IEFIFGLPLE | PSLNYTIEER |
TFAQRLMRYW | ANFARTGDPN | DPRDPKAPQW | PPYTAGAQQY | VSLNLRPLEV |
RRGLRAQACA | FWNRFLPKLL | SATDTLDEAE | RQWKAEFHRW | SSYMVHWKNQ |
FDHYSKQDRC | SDL
This product has not yet been referenced specifically in any publications.
"Variability of AChE, BChE, and ChAT genes in the late-onset form of Alzheimer's disease and relationships with response to treatment with Donepezil and Rivastigmine."
"Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II."
"Expression of three alternative acetylcholinesterase messenger RNAs in human tumor cell lines of different tissue origins."
"Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding."
"Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia."
"Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients."
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."
"Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?"
"Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation."
"Donepezil, a potent acetylcholinesterase inhibitor, induces caspase-dependent apoptosis in human promyelocytic leukemia HL-60 cells."
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