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ACHE (GeneName), Acetylcholinesterase (ProteinName), ACES_BOVIN.
Product Name:

Bovine ACHE/ Acetylcholinesterase ELISA Kit

Cat.#:

E1195b

Brand:
EIAab®
Regulatory Status:
Alternative:

AChE

Detection Method:
ELISA
Assay Type:
Sandwich
Detection Range:
0.78-50ng/mL
Sensitivity:
0.34ng/mL
Specificity:
Natural and recombinant bovine Acetylcholinesterase
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Assay Procedure:
Assay Procedure
Research Area:
Neurosciences
Bovine ACHE ELISA Kit
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Bovine ACHE ELISA Kit
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Product Datasheets
Instruction: Down Instruction
MSDS: MSDS


General Annotation


Sub Unit:
Interacts with PRIMA1. The interaction with PRIMA1 is required to anchor it to the basal lamina of cells and organize into tetramers (By similarity). Isoform H generates GPI-anchored dimers; disulfide linked. Isoform T generates multiple structures, ranging from monomers and dimers to collagen-tailed and hydrophobic-tailed forms, in which catalytic tetramers are associated with anchoring proteins that attach them to the basal lamina or to cell membranes. In the collagen-tailed forms, isoform T subunits are associated with a specific collagen, COLQ, which triggers the formation of isoform T tetramers, from monomers and dimers.


Function:
Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.


Subcellular Location:
Isoform H Cell membrane Lipid-anchor GPI-anchor Extracellular side


This product has not yet been referenced specifically in any publications.

[1].
"Variability of AChE, BChE, and ChAT genes in the late-onset form of Alzheimer's disease and relationships with response to treatment with Donepezil and Rivastigmine."

[2].
"Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II."

[3].
"Expression of three alternative acetylcholinesterase messenger RNAs in human tumor cell lines of different tissue origins."

[4].
"Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding."

[5].
"Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia."

[6].
"Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients."

[7].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

[8].
"Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?"

[9].
"Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation."

[10].
"Donepezil, a potent acetylcholinesterase inhibitor, induces caspase-dependent apoptosis in human promyelocytic leukemia HL-60 cells."
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