Acer2 (GeneName), Alkaline ceramidase 2 (ProteinName), ACER2_MOUSE.
Product Name:
Mouse Acer2/ Alkaline ceramidase 2 ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
AlkCDase 2, Acylsphingosine deacylase 3-like, Cancer-related gene liver 1 protein, CRG-L1, N-acylsphingosine amidohydrolase 3-like, Asah3l
Detection Method:
ELISA
Specificity:
Natural and recombinant mouse Alkaline ceramidase 2
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
N/A
Function:
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1-phosphate.
Subcellular Location:
Golgi apparatus membrane
Multi-pass membrane protein
Database link
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion."
[2].
"Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2)."
[3].
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."
[4].
"Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P."
[6].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
[7].
"Large-scale cDNA transfection screening for genes related to cancer development and progression."
[8].
"Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response."
[10].
"Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells."
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