Acer2 (基因名), Alkaline ceramidase 2 (蛋白名), ACER2_MOUSE.
Mouse Acer2/ Alkaline ceramidase 2 ELISA Kit
AlkCDase 2, Acylsphingosine deacylase 3-like, Cancer-related gene liver 1 protein, CRG-L1, N-acylsphingosine amidohydrolase 3-like, Asah3l
Natural and recombinant mouse Alkaline ceramidase 2
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1-phosphate.
Golgi apparatus membrane Multi-pass membrane protein
MGAPHWWDHL | RAGSSEVDWC | EDNYTIVPAI | AEFYNTISNV | LFFILPPICM |
CLFRQYATCF | NSGIYLIWTL | LVVVGIGSVY | FHATLSFLGQ | MLDELAILWV |
LMCALAMWFP | RRYLPKIFRN | DRGRFKAVVC | VLSAITTCLA | FIKPAINNIS |
LMILGLPCTA | LLVAELKRCD | NVRVFKLGLF | SGLWWTLALF | CWISDQAFCE |
LLSSFHFPYL | HCVWHILICL | ASYLGCVCFA | YFDAASEIPE | QGPVIRFWPS |
EKWAFIGVPY | VSLLCAHKKS | PVKIT
"Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion."
"Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2)."
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."
"Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P."
"DNA sequence and analysis of human chromosome 9."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"Large-scale cDNA transfection screening for genes related to cancer development and progression."
"Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response."
"Regulation of alkaline ceramidase activity by the c-Src-mediated pathway."
"Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells."
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