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ACER2 (GeneName), Alkaline ceramidase 2 (ProteinName), ACER2_HUMAN.
Product Name:

Human ACER2/ Alkaline ceramidase 2 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

AlkCDase 2, Acylsphingosine deacylase 3-like, N-acylsphingosine amidohydrolase 3-like, ASAH3L, PP11646

Detection Method:
ELISA
Specificity:
Natural and recombinant human Alkaline ceramidase 2
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Human ACER2 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
N/A


Function:
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. The substrate preference is D-erythro-C(18:1)-, C(20:1)-, C(20:4)-ceramide > D-erythro-C(16:0)-, C(18:0), C(20:0)-ceramide > D-erythro-C(24:1)-ceramide > D-erythro-C(12:0)-ceramide, D-erythro-C(14:0)-ceramides > D-erythro-C(24:0)-ceramide > D-erythro-C(6:0)-ceramide. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1-phosphate.


Subcellular Location:
Golgi apparatus membrane Multi-pass membrane protein


This product has not yet been referenced specifically in any publications.

[1].
"Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion."

[2].
"Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2)."

[3].
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."

[4].
"Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P."

[5].
"DNA sequence and analysis of human chromosome 9."

[6].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[7].
"Large-scale cDNA transfection screening for genes related to cancer development and progression."

[8].
"Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response."

[9].
"Regulation of alkaline ceramidase activity by the c-Src-mediated pathway."

[10].
"Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells."
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