Acer1 (GeneName), Alkaline ceramidase 1 (ProteinName), ACER1_MOUSE.
Product Name:
Mouse Acer1/ Alkaline ceramidase 1 ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
AlkCDase 1, Acylsphingosine deacylase 3, N-acylsphingosine amidohydrolase 3, Asah3
Detection Method:
ELISA
Specificity:
Natural and recombinant mouse Alkaline ceramidase 1
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
N/A
Function:
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo-phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids.
Subcellular Location:
Endoplasmic reticulum membrane
Multi-pass membrane protein
Database link
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides."
[2].
"Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis."
[3].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
[4].
"Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells."
[5].
"Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes."
[6].
"Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate."
[7].
"Large-scale identification of human genes implicated in epidermal barrier function."
[8].
"[Molecular evolution of neutral ceramidase: signalling molecule and virulence factor]."
[9].
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."
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