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ACER1 (GeneName), Alkaline ceramidase 1 (ProteinName), ACER1_HUMAN.
Product Name:

Human ACER1/ Alkaline ceramidase 1 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

AlkCDase 1, Acylsphingosine deacylase 3, N-acylsphingosine amidohydrolase 3, ASAH3

Detection Method:
ELISA
Specificity:
Natural and recombinant human Alkaline ceramidase 1
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Human ACER1 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
N/A


Function:
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo-phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids.


Subcellular Location:
Endoplasmic reticulum membrane Multi-pass membrane protein


This product has not yet been referenced specifically in any publications.

[1].
"Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides."

[2].
"Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis."

[3].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[4].
"Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells."

[5].
"Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes."

[6].
"Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate."

[7].
"Large-scale identification of human genes implicated in epidermal barrier function."

[8].
"[Molecular evolution of neutral ceramidase: signalling molecule and virulence factor]."

[9].
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."
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