ACER1 (GeneName), Alkaline ceramidase 1 (ProteinName), ACER1_HUMAN.
Human ACER1/ Alkaline ceramidase 1 ELISA Kit
AlkCDase 1, Acylsphingosine deacylase 3, N-acylsphingosine amidohydrolase 3, ASAH3
Natural and recombinant human Alkaline ceramidase 1
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo-phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids.
Endoplasmic reticulum membrane Multi-pass membrane protein
MPSIFAYQSS | EVDWCESNFQ | YSELVAEFYN | TFSNIPFFIF | GPLMMLLMHP |
YAQKRSRYIY | VVWVLFMIIG | LFSMYFHMTL | SFLGQLLDEI | AILWLLGSGY |
SIWMPRCYFP | SFLGGNRSQF | IRLVFITTVV | STLLSFLRPT | VNAYALNSIA |
LHILYIVCQE | YRKTSNKELR | HLIEVSVVLW | AVALTSWISD | RLLCSFWQRI |
HFFYLHSIWH | VLISITFPYG | MVTMALVDAN | YEMPGETLKV | RYWPRDSWPV |
GLPYVEIRGD | DKDC
This product has not yet been referenced specifically in any publications.
"Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides."
"Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells."
"Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes."
"Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate."
"Large-scale identification of human genes implicated in epidermal barrier function."
"[Molecular evolution of neutral ceramidase: signalling molecule and virulence factor]."
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."
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