Home > ELISA Kit > Mouse Ace2 ELISA Kit

Ace2 (GeneName), Angiotensin-converting enzyme 2 (ProteinName), ACE2_MOUSE.

Product Name:

Mouse Ace2/ Angiotensin-converting enzyme 2 ELISA Kit

Cat.#:

E1886m

Brand:

EIAab^®

Regulatory Status:

RUO

Alternative:

ACE-related carboxypeptidase

Detection Method:

ELISA

Assay Type:

Sandwich

Detection Range:

0.312-20ng/mL

Sensitivity:

0.174ng/mL

Specificity:

Natural and recombinant mouse Angiotensin-converting enzyme 2

Sample Type:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Sample Data:

Assay Procedure:

Research Area:

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Mouse Ace2 ELISA Kit

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Product Datasheets

Datasheet:

Instruction:

MSDS:

Data
Citations
Publication
Sequence / 3D
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General Annotation

Sub Unit:

Interacts with ITGB1 and the catalytically active form of TMPRSS2 (By similarity). Weakly interacts with SARS-CoV S protein.

Function:

Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. May have a protective role in acute lung injury.

Subcellular Location:

Cell membrane Single-pass type I membrane protein Cytoplasm Detected in both cell membrane and cytoplasm in neurons.

Database link

UniGene:

Mm.13451

SMR:

Q8R0I0

STRING:

10090.ENSMUSP00000073626

KEGG:

mmu:70008

Pfam:

PF16959

Uniprot:

Q8R0I0

Related Product

Human ACE2 ELISA Kit

Rat Ace2 ELISA Kit

Bovine ACE2 ELISA Kit

Human ACE2 CLIA Kit

Rat Ace2 CLIA Kit

Sequence length:

805

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805:

AQTSF

3D Structure:

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Valid Sequence:

This product has not yet been referenced specifically in any publications.

[1].

"A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9."

(PMID: 10969042)

[2].

"[Relationship of angiotensin-converting enzyme 2 gene polymorphisms and vulnerability to coronary heart disease in patients with type 2 diabetes mellitus]."

(PMID: 18753062)

[3].

"Polymorphisms of ACE2 gene are associated with essential hypertension and antihypertensive effects of Captopril in women."

(PMID: 17473847)

[4].

"Association of angiotensin-converting enzyme 2 (ACE2) gene polymorphisms with parameters of left ventricular hypertrophy in men. Results of the MONICA Augsburg echocardiographic substudy."

(PMID: 16283142)

[5].

"Association analysis of common variants of ELN, NOS2A, APOE and ACE2 to intracranial aneurysm."

(PMID: 16574921)

[6].

"Myocardial infarction increases ACE2 expression in rat and humans."

(PMID: 15671045)

[7].

"Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2."

(PMID: 15791205)

[8].

"Identification of an alternative 5'-untranslated exon and new polymorphisms of angiotensin-converting enzyme 2 gene: lack of association with SARS in the Vietnamese population."

(PMID: 15937940)

[9].

"Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2)."

(PMID: 15983030)

[10].

"Polymorphisms in the gene encoding angiotensin I converting enzyme 2 and diabetic nephropathy."

(PMID: 16211375)

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