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Acd (GeneName), Adrenocortical dysplasia protein homolog (ProteinName), ACD_RAT.
Product Name:

Rat Acd/ Adrenocortical dysplasia protein homolog ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Detection Method:
ELISA
Specificity:
Natural and recombinant rat Adrenocortical dysplasia protein homolog
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Rat Acd ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Forms heterodimers with POT1. Identified in a complex with POT1 and single-stranded telomeric DNA. Interacts with STN1 and TINF2.


Function:
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.


Subcellular Location:
Nucleus Chromosome Telomere


This product has not yet been referenced specifically in any publications.

[1].
"PTOP interacts with POT1 and regulates its localization to telomeres."

[2].
"POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex."

[3].
"TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres."

[4].
"Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins."

[5].
"Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1."

[6].
"Genetic variants in eleven telomere-associated genes and the risk of incident cardio/cerebrovascular disease: The Women's Genome Health Study."

[7].
"Polymorphisms in telomere-associated genes, breast cancer susceptibility and prognosis."

[8].
"OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation."

[9].
"The POT1-TPP1 telomere complex is a telomerase processivity factor."

[10].
"Novel polymorphisms and lack of mutations in the ACD gene in patients with ACTH resistance syndromes."
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