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ACADSB (GeneName), Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (ProteinName), ACDSB_BOVIN.
Product Name:

Bovine ACADSB/ Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ELISA Kit

Cat.#:

E12556b

Brand:
EIAab®
Regulatory Status:
Alternative:

SBCAD, 2-methyl branched chain acyl-CoA dehydrogenase, 2-MEBCAD, 2-methylbutyryl-coenzyme A dehydrogenase, 2-methylbutyryl-CoA dehydrogenase

Detection Method:
ELISA
Specificity:
Natural and recombinant bovine Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Cardiovascular
Bovine ACADSB ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Homotetramer.


Function:
Has greatest activity toward short branched chain acyl-CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl-CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent.


Subcellular Location:
Mitochondrion matrix


This product has not yet been referenced specifically in any publications.

[1].
"Short/branched-chain acyl-CoA dehydrogenase deficiency due to an IVS3+3A>G mutation that causes exon skipping."

[2].
"Isolated 2-methylbutyrylglycinuria caused by short/branched-chain acyl-CoA dehydrogenase deficiency: identification of a new enzyme defect, resolution of its molecular basis, and evidence for distinct acyl-CoA dehydrogenases in isoleucine and valine metabolism."

[3].
"Localization of short/branched chain acyl-CoA dehydrogenase (ACADSB) to human chromosome 10."

[4].
"Isolation and expression of a cDNA encoding the precursor for a novel member (ACADSB) of the acyl-CoA dehydrogenase gene family."

[5].
"Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression."

[6].
"Association of genetic polymorphisms of ACADSB and COMT with human hypertension."

[7].
"A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease."

[8].
"Inborn errors of isoleucine degradation: a review."

[9].
"2-ethylhydracrylic aciduria in short/branched-chain acyl-CoA dehydrogenase deficiency: application to diagnosis and implications for the R-pathway of isoleucine oxidation."

[10].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
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