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Accn3 (GeneName), Amiloride-sensitive cation channel 3 (ProteinName), ACCN3_RAT.
Product Name:

Rat Accn3/ Amiloride-sensitive cation channel 3 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Acid-sensing ion channel 3, ASIC3, Dorsal root ASIC, DRASIC, Asic3, Drasic

Detection Method:
ELISA
Specificity:
Natural and recombinant rat Amiloride-sensitive cation channel 3
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Rat Accn3 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with STOM, LIN7B, MAGI1 and GOPC (By similarity). Interacts with DLG4 and ACCN1.


Function:
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.


Subcellular Location:
Cytoplasm Cell membrane Multi-pass membrane protein In part cytoplasmic in cochlea cells (By similarity). Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4.


This product has not yet been referenced specifically in any publications.
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