Accn3 (GeneName), Amiloride-sensitive cation channel 3 (ProteinName), ACCN3_MOUSE.
Mouse Accn3/ Amiloride-sensitive cation channel 3 ELISA Kit
Acid-sensing ion channel 3, ASIC3, Dorsal root ASIC, DRASIC, Asic3, Drasic
Natural and recombinant mouse Amiloride-sensitive cation channel 3
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with STOM, DLG4 and ACCN1 (By similarity). Interacts with LIN7B, MAGI1/BAIAP1 and GOPC.
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.
Cell membrane Multi-pass membrane protein Cytoplasm Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4 (By similarity). In part cytoplasmic in cochlea cells.
MKPPSGLEEA | QRRQASDIRV | FANSCTMHGL | GHIFGPGGLT | LRRGLWATAV |
LLSLAAFLYQ | VAERVRYYGE | FHHKTTLDER | ESHQLTFPAV | TLCNINPLRR |
SRLTPNDLHW | AGTALLGLDP | AEHAAYLRAL | GQPPAPPGFM | PSPTFDMAQL |
YARAGHSLED | MLLDCRYRGQ | PCGPENFTVI | FTRMGQCYTF | NSGAQGAELL |
TTPKGGAGNG | LEIMLDVQQE | EYLPIWKDME | ETPFEVGIRV | QIHGQEEPPA |
IDQLGFGAAP | GHQTFVSCQQ | QQLSFLPPPW | GDCNTASVDP | DFDPEPSDPL |
GSPSSSPPYS | LIGCRLACES | RYVARKCGCR | MMHMPGNSPV | CSPQQYKDCA |
SPALDAMLRK | DTCVCPNPCA | TTRYAKELSM | VRIPSRASAR | YLARKYNRSE |
TYITENVLVL | DIFFEALNYE | AVEQKAAYEV | SELLGDIGGQ | MGLFIGASLL |
TILEILDYLC | EVFQDRVLGY | FWNRRSSQRR | SGNTLLQEEL | NGHRTHVPHL |
SLGPRPPTAP | SAVTKTLAAS | HRTCYLVTRL |
This product has not yet been referenced specifically in any publications.
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