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Accn3 (GeneName), Amiloride-sensitive cation channel 3 (ProteinName), ACCN3_MOUSE.

Product Name:

Mouse Accn3/ Amiloride-sensitive cation channel 3 ELISA Kit

Cat.#:

Brand:

EIAab^®

Regulatory Status:

RUO

Alternative:

Acid-sensing ion channel 3, ASIC3, Dorsal root ASIC, DRASIC, Asic3, Drasic

Detection Method:

ELISA

Specificity:

Natural and recombinant mouse Amiloride-sensitive cation channel 3

Sample Type:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Sample Data:

Research Area:

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Mouse Accn3 ELISA Kit

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Product Datasheets

Data
Citations
Sequence / 3D
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General Annotation

Sub Unit:

Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with STOM, DLG4 and ACCN1 (By similarity). Interacts with LIN7B, MAGI1/BAIAP1 and GOPC.

Function:

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.

Subcellular Location:

Cell membrane Multi-pass membrane protein Cytoplasm Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4 (By similarity). In part cytoplasmic in cochlea cells.

Database link

Uniprot:

Q6X1Y6

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