Accn2 (GeneName), Amiloride-sensitive cation channel 2, neuronal (ProteinName), ACCN2_RAT.
Rat Accn2/ Amiloride-sensitive cation channel 2, neuronal ELISA Kit
Acid-sensing ion channel 1, ASIC1, Brain sodium channel 2, BNaC2, Asic1, Bnac2
Natural and recombinant rat Amiloride-sensitive cation channel 2, neuronal
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with STOM and PRKCABP (By similarity). Interacts with ACCN1.
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Isoform 3 discrimates stronger than isoform 1 between monovalent cations. Isoform 3 can flux Ca(2+) while isoform 1 cannot. Heteromeric channels composed of isoform 2 and isoform 3 are active but have a lower pH-sensitivity. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties.
Cell membrane Multi-pass membrane protein Localizes in synaptosomes at dendritic synapses of neurons. Colocalizes with DLG4.
MELKTEEEEV | GGVQPVSIQA | FASSSTLHGL | AHIFSYERLS | LKRALWALCF |
LGSLAVLLCV | CTERVQYYFC | YHHVTKLDEV | AASQLTFPAV | TLCNLNEFRF |
SQVSKNDLYH | AGELLALLNN | RYEIPDTQMA | DEKQLEILQD | KANFRSFKPK |
PFNMREFYDR | AGHDIRDMLL | SCHFRGEACS | AEDFKVVFTR | YGKCYTFNSG |
QDGRPRLKTM | KGGTGNGLEI | MLDIQQDEYL | PVWGETDETS | FEAGIKVQIH |
SQDEPPFIDQ | LGFGVAPGFQ | TFVSCQEQRL | IYLPSPWGTC | NAVTMDSDFF |
DSYSITACRI | DCETRYLVEN | CNCRMVHMPG | DAPYCTPEQY | KECADPALDF |
LVEKDQEYCV | CEMPCNLTRY | GKELSMVKIP | SKASAKYLAK | KFNKSEQYIG |
ENILVLDIFF | EVLNYETIEQ | KKAYEIAGLL | GDIGGQMGLF | IGASILTVLE |
LFDYAYEVIK | HRLCRRGKCQ | KEAKRSSADK | GVALSLDDVK | RHNPCESLRG |
HPAGMTYAAN | ILPHHPARGT | FEDFTC
This product has not yet been referenced specifically in any publications.
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