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首页  >  酶联免疫试剂盒  >  Rat Accn2 ELISA Kit
Accn2 (基因名), Amiloride-sensitive cation channel 2, neuronal (蛋白名), ACCN2_RAT.
产品名称:

Rat Accn2/ Amiloride-sensitive cation channel 2, neuronal ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Acid-sensing ion channel 1, ASIC1, Brain sodium channel 2, BNaC2, Asic1, Bnac2

检测方法:
ELISA
特异性:
Natural and recombinant rat Amiloride-sensitive cation channel 2, neuronal
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Rat Accn2 ELISA Kit
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Rat Accn2 ELISA Kit
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产品说明书


通用注释


亚单元:
Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with STOM and PRKCABP (By similarity). Interacts with ACCN1.


功能:
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Isoform 3 discrimates stronger than isoform 1 between monovalent cations. Isoform 3 can flux Ca(2+) while isoform 1 cannot. Heteromeric channels composed of isoform 2 and isoform 3 are active but have a lower pH-sensitivity. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties.


亚细胞位置:
Cell membrane Multi-pass membrane protein Localizes in synaptosomes at dendritic synapses of neurons. Colocalizes with DLG4.


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