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ACCN2 (GeneName), Amiloride-sensitive cation channel 2, neuronal (ProteinName), ACCN2_HUMAN.

Product Name:

Human ACCN2/ Amiloride-sensitive cation channel 2, neuronal ELISA Kit

Cat.#:

Brand:

EIAab^®

Regulatory Status:

RUO

Alternative:

Acid-sensing ion channel 1, ASIC1, Brain sodium channel 2, BNaC2, ASIC1, BNAC2

Detection Method:

ELISA

Specificity:

Natural and recombinant human Amiloride-sensitive cation channel 2, neuronal

Sample Type:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Sample Data:

Research Area:

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Human ACCN2 ELISA Kit

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Product Datasheets

Data
Citations
Sequence / 3D
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General Annotation

Sub Unit:

Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with STOM and ACCN1 (By similarity). Interacts with PRKCABP.

Function:

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.

Subcellular Location:

Cell membrane Multi-pass membrane protein Localizes in synaptosomes at dendritic synapses of neurons. Colocalizes with DLG4.

Database link

Uniprot:

P78348

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