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ACCN2 (GeneName), Amiloride-sensitive cation channel 2, neuronal (ProteinName), ACCN2_HUMAN.
Product Name:

Human ACCN2/ Amiloride-sensitive cation channel 2, neuronal ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Acid-sensing ion channel 1, ASIC1, Brain sodium channel 2, BNaC2, ASIC1, BNAC2

Detection Method:
ELISA
Specificity:
Natural and recombinant human Amiloride-sensitive cation channel 2, neuronal
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Human ACCN2 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with STOM and ACCN1 (By similarity). Interacts with PRKCABP.


Function:
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.


Subcellular Location:
Cell membrane Multi-pass membrane protein Localizes in synaptosomes at dendritic synapses of neurons. Colocalizes with DLG4.


This product has not yet been referenced specifically in any publications.
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