Dbi (GeneName), Acyl-CoA-binding protein (ProteinName), ACBP_RAT.
Rat Dbi/ Acyl-CoA-binding protein ELISA Kit
ACBP, Diazepam-binding inhibitor, DBI, Endozepine, EP
Natural and recombinant rat Acyl-CoA-binding protein
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.
Endoplasmic reticulum Golgi apparatus Golgi localization is dependent on ligand binding.
This product has not yet been referenced specifically in any publications.
"High resolution crystal structures of unliganded and liganded human liver ACBP reveal a new mode of binding for the acyl-CoA ligand."
"Association of acyl-CoA-binding protein (ACBP) single nucleotide polymorphisms and type 2 diabetes in two German study populations."
"Identification of new acyl-CoA binding protein transcripts in human and mouse."
"Specific regulation of low-abundance transcript variants encoding human Acyl-CoA binding protein (ACBP) isoforms."
"Identification of a novel human Acyl-CoA binding protein isoform with a unique C-terminal domain."
"ACBP knockdown leads to down-regulation of genes encoding rate-limiting enzymes in cholesterol and fatty acid metabolism."
"Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment."
"Genetical genomic determinants of alcohol consumption in rats and humans."
"Transcriptional regulation of HMG-CoA synthase and HMG-CoA reductase genes by human ACBP."
"Association of a Met88Val diazepam binding inhibitor (DBI) gene polymorphism and anxiety disorders with panic attacks."
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