Dbi (GeneName), Acyl-CoA-binding protein (ProteinName), ACBP_MOUSE.
Product Name:
Mouse Dbi/ Acyl-CoA-binding protein ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
ACBP, Diazepam-binding inhibitor, DBI, Endozepine, EP
Detection Method:
ELISA
Specificity:
Natural and recombinant mouse Acyl-CoA-binding protein
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Neurosciences
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
Monomer.
Function:
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.
Subcellular Location:
Endoplasmic reticulum
Golgi apparatus
Golgi localization is dependent on ligand binding.
Database link
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"High resolution crystal structures of unliganded and liganded human liver ACBP reveal a new mode of binding for the acyl-CoA ligand."
[2].
"Association of acyl-CoA-binding protein (ACBP) single nucleotide polymorphisms and type 2 diabetes in two German study populations."
[3].
"Identification of new acyl-CoA binding protein transcripts in human and mouse."
[4].
"Specific regulation of low-abundance transcript variants encoding human Acyl-CoA binding protein (ACBP) isoforms."
[5].
"Identification of a novel human Acyl-CoA binding protein isoform with a unique C-terminal domain."
[6].
"ACBP knockdown leads to down-regulation of genes encoding rate-limiting enzymes in cholesterol and fatty acid metabolism."
[7].
"Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment."
[9].
"Transcriptional regulation of HMG-CoA synthase and HMG-CoA reductase genes by human ACBP."
[10].
"Association of a Met88Val diazepam binding inhibitor (DBI) gene polymorphism and anxiety disorders with panic attacks."
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