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Acap1 (GeneName), Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (ProteinName), ACAP1_MOUSE.
Product Name:

Mouse Acap1/ Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Centaurin-beta-1, Cnt-b1, Centb1, Kiaa0050

Detection Method:
ELISA
Specificity:
Natural and recombinant mouse Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Mouse Acap1 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Banana-shaped homodimer laterally assembling into tetramers, the tetramers further pack helically onto the membrane. Interacts with GTP-bound ARF6. Interacts with third cytoplasmic loop of SLC2A4/GLUT4. Interacts with CLTC. Interacts with GULP1. Forms a complex with GDP-bound ARF6 and GULP1. Interacts with ITGB1; required for ITGB1 recycling.


Function:
GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.


Subcellular Location:
Recycling endosome membrane Peripheral membrane protein Cytoplasmic side


This product has not yet been referenced specifically in any publications.

[1].
"ACAPs are arf6 GTPase-activating proteins that function in the cell periphery."

[2].
"An ACAP1-containing clathrin coat complex for endocytic recycling."

[3].
"Cooperation of phosphoinositides and BAR domain proteins in endosomal tubulation."

[4].
"Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry."

[5].
"Mechanistic insights into regulated cargo binding by ACAP1 protein."

[6].
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."

[7].
"Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study."

[8].
"Centaurin beta1 down-regulates nucleotide-binding oligomerization domains 1- and 2-dependent NF-kappaB activation."

[9].
"Phosphorylation of ACAP1 by Akt regulates the stimulation-dependent recycling of integrin beta1 to control cell migration."

[10].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
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