Acap1 (GeneName), Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (ProteinName), ACAP1_MOUSE.
Mouse Acap1/ Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 ELISA Kit
Centaurin-beta-1, Cnt-b1, Centb1, Kiaa0050
Natural and recombinant mouse Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Banana-shaped homodimer laterally assembling into tetramers, the tetramers further pack helically onto the membrane. Interacts with GTP-bound ARF6. Interacts with third cytoplasmic loop of SLC2A4/GLUT4. Interacts with CLTC. Interacts with GULP1. Forms a complex with GDP-bound ARF6 and GULP1. Interacts with ITGB1; required for ITGB1 recycling.
GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.
Recycling endosome membrane Peripheral membrane protein Cytoplasmic side
MTVKLDFEEC | LKDSPRFRAS | IELVETEVSE | LETRLEKLLK | LGSCLLESGQ |
HYLAAGRAFV | VGICDLARLG | PPEPMMAECL | EKFTVSLNHK | LDSHAELLDA |
TQHTLQQQIQ | TLVKEGLRGF | REARRDFWRG | AENLEAALTH | NAEVPRRRVQ |
EAEEAGTALR | TARAGYRSRA | LDYALQVNVI | EDKRKFDIME | FVLRLVEAQA |
TYFQQGHEEL | NRLAQYRKEL | GTQLHNLVLN | SARQKRDMEQ | RHVLLKQKEL |
GGEEPEPSLK | EGPSGLVMEG | HLFKRASNAF | KTWSRRWFTI | QNNQLVYQKK |
YKDPVTVVVD | DLRLCTVKLC | PDSERRFCFE | VVSTSKSCFL | QADSERLLQL |
WVSAVQSSIA | SAFSQAHLEN | SPRGPGQVSG | YHAPGSAATL | ACGGAARGRE |
SGGVGQVAAQ | VQSVDGNAQC | CDCREPAPEW | ASINLGVTLC | IQCSGIHRSL |
GVHFSKVRSL | TLDSWEPELV | KLMCELGNVI | INQIYEARVE | AMAVKKPGPS |
CSRQEKEAWI | HAKYVEKKFL | TKLPEIRGRR | GGRGPPRGHP | PVPPKPPIRP |
HSGIVRSKSE | CPSDDMGSLH | PGALLFQAAG | HPPSLPTMAD | ALAHGADVNW |
VNVGQGNATP | LIRATAANSL | LACEFLLQNG | ANVNQADSAG | RGPLHHATIL |
GHTGLACLFL | KRGADLGARD | TEGRDPLTIA | METTNADIVT | LLRLAKMREA |
EAAQGQAGDE | TYLDIFRDFS | LMASDDPEKL | SRRSHDLHTL |
This product has not yet been referenced specifically in any publications.
"ACAPs are arf6 GTPase-activating proteins that function in the cell periphery."
"An ACAP1-containing clathrin coat complex for endocytic recycling."
"Cooperation of phosphoinositides and BAR domain proteins in endosomal tubulation."
"Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry."
"Mechanistic insights into regulated cargo binding by ACAP1 protein."
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."
"Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study."
"Centaurin beta1 down-regulates nucleotide-binding oligomerization domains 1- and 2-dependent NF-kappaB activation."
"Phosphorylation of ACAP1 by Akt regulates the stimulation-dependent recycling of integrin beta1 to control cell migration."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
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