ACAP1 (GeneName), Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (ProteinName), ACAP1_HUMAN.
Product Name:
Human ACAP1/ Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
Centaurin-beta-1, Cnt-b1, CENTB1, KIAA0050
Detection Method:
ELISA
Specificity:
Natural and recombinant human Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
- Data
- Citations
- Publication
- Sequence / 3D
- Feedback Wall (0)
General Annotation
Sub Unit:
Banana-shaped homodimer laterally assembling into tetramers, the tetramers further pack helically onto the membrane. Interacts with GTP-bound ARF6. Interacts with third cytoplasmic loop of SLC2A4/GLUT4. Interacts with CLTC. Interacts with GULP1. Forms a complex with GDP-bound ARF6 and GULP1. Interacts with ITGB1; required for ITGB1 recycling.
Function:
GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.
Subcellular Location:
Recycling endosome membrane
Peripheral membrane protein
Cytoplasmic side
Database link
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"ACAPs are arf6 GTPase-activating proteins that function in the cell periphery."
[3].
"Cooperation of phosphoinositides and BAR domain proteins in endosomal tubulation."
[4].
"Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry."
[6].
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."
[7].
"Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study."
[8].
"Centaurin beta1 down-regulates nucleotide-binding oligomerization domains 1- and 2-dependent NF-kappaB activation."
[9].
"Phosphorylation of ACAP1 by Akt regulates the stimulation-dependent recycling of integrin beta1 to control cell migration."
[10].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
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