Acad9 (GeneName), Acyl-CoA dehydrogenase family member 9, mitochondrial (ProteinName), ACAD9_MOUSE.
Product Name:
Mouse Acad9/ Acyl-CoA dehydrogenase family member 9, mitochondrial ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
ACAD-9
Detection Method:
ELISA
Specificity:
Natural and recombinant mouse Acyl-CoA dehydrogenase family member 9, mitochondrial
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Cardiovascular
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
Part of the mitochondrial complex I assembly (MCIA) complex. The complex comprises at least TMEM126B, NDUFAF1, ECSIT, and ACAD9 (By similarity). Interacts with NDUFAF1 and ECSIT.
Function:
Required for mitochondrial complex I assembly (By similarity). Has a dehydrogenase activity on palmitoyl-CoA (C16:0) and stearoyl-CoA (C18:0). It is three times more active on palmitoyl-CoA then on stearoyl-CoA. However, it does not play a primary role in long-chain fatty acid oxidation (By similarity). Has little activity on octanoyl-CoA (C8:0), butyryl-CoA (C4:0) or isovaleryl-CoA (5:0).
Subcellular Location:
Mitochondrion
Database link
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"Cloning and functional characterization of ACAD-9, a novel member of human acyl-CoA dehydrogenase family."
[2].
"Acyl-CoA dehydrogenase 9 is required for the biogenesis of oxidative phosphorylation complex I."
[3].
"Exome sequencing identifies ACAD9 mutations as a cause of complex I deficiency."
[4].
"A new genetic disorder in mitochondrial fatty acid beta-oxidation: ACAD9 deficiency."
[5].
"ACAD9, a complex I assembly factor with a moonlighting function in fatty acid oxidation deficiencies."
[6].
"Riboflavin-responsive oxidative phosphorylation complex I deficiency caused by defective ACAD9: new function for an old gene."
[7].
"Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression."
[8].
"Carnitine palmitoyltransferase I and Acyl-CoA dehydrogenase 9 in retina: insights of retinopathy in mitochondrial trifunctional protein defects."
[9].
"Acyl-CoA dehydrogenase 9 (ACAD 9) is the long-chain acyl-CoA dehydrogenase in human embryonic and fetal brain."
[10].
"Human acyl-CoA dehydrogenase-9 plays a novel role in the mitochondrial beta-oxidation of unsaturated fatty acids."
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