Acacb (GeneName), Acetyl-CoA carboxylase 2 (ProteinName), ACACB_MOUSE.
Product Name:
Mouse Acacb/ Acetyl-CoA carboxylase 2 ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
ACC-beta, Acc2, Accb
Detection Method:
ELISA
Specificity:
Natural and recombinant mouse Acetyl-CoA carboxylase 2
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
Monomer, homodimer, and homotetramer. Can form filamentous polymers. Interacts with MID1IP1; interaction with MID1IP1 promotes oligomerization and increases its activity.
Function:
Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA (By similarity). Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase (By similarity). Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (PubMed:11283375, PubMed:12920182, PubMed:15677334, PubMed:18487439, PubMed:22362781). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl-CoA-dependent inhibition of carnitine palmitoyltransferase 1 (PubMed:10677481).
Subcellular Location:
Mitochondrion
Nucleus
Endomembrane system
May associate with membranes.
Database link
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"A single nucleotide polymorphism within the acetyl-coenzyme A carboxylase beta gene is associated with proteinuria in patients with type 2 diabetes."
[2].
"ACC2 is expressed at high levels in human white adipose and has an isoform with a novel N-terminus [corrected]."
[3].
"Acetyl-coenzyme A carboxylase alpha gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels."
[4].
"Exploring genetic variations that may be associated with the direct effects of some antipsychotics on lipid levels."
[5].
"Expression, purification, and characterization of human and rat acetyl coenzyme A carboxylase (ACC) isozymes."
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