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ACACB (GeneName), Acetyl-CoA carboxylase 2 (ProteinName), ACACB_HUMAN.
Product Name:

Human ACACB/ Acetyl-CoA carboxylase 2 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

ACC-beta, ACC2, ACCB

Detection Method:
ELISA
Specificity:
Natural and recombinant human Acetyl-CoA carboxylase 2
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Human ACACB ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Monomer, homodimer, and homotetramer. Can form filamentous polymers. Interacts with MID1IP1; interaction with MID1IP1 promotes oligomerization and increases its activity.


Function:
Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl-CoA-dependent inhibition of carnitine palmitoyltransferase 1.


Subcellular Location:
Mitochondrion Nucleus Endomembrane system May associate with membranes.


This product has not yet been referenced specifically in any publications.

[1].
"A single nucleotide polymorphism within the acetyl-coenzyme A carboxylase beta gene is associated with proteinuria in patients with type 2 diabetes."

[2].
"ACC2 is expressed at high levels in human white adipose and has an isoform with a novel N-terminus [corrected]."

[3].
"Acetyl-coenzyme A carboxylase alpha gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels."

[4].
"Exploring genetic variations that may be associated with the direct effects of some antipsychotics on lipid levels."

[5].
"Expression, purification, and characterization of human and rat acetyl coenzyme A carboxylase (ACC) isozymes."
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