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首页  >  酶联免疫试剂盒  >  Human ACACA ELISA Kit
ACACA (基因名), Acetyl-CoA carboxylase 1 (蛋白名), ACACA_HUMAN.
产品名称:

Human ACACA/ Acetyl-CoA carboxylase 1 ELISA Kit
乙酰辅酶A羧化酶1

货号:

E1284h

商标:
EIAab®
监管等级:
别名:

ACC1, ACAC, ACC1, ACCA, Acetyl-Coenzyme A carboxylase alpha, ACC-alpha

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
32.1-2000pg/mL
灵敏度:
15.7pg/mL
特异性:
Natural and recombinant human Acetyl-CoA carboxylase 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Metabolism
Human ACACA ELISA Kit
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Human ACACA ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS


精密度
批内差:已知浓度的3个样本在一个板子内重复检测20次,以评估批内精密度。
批内 CV: ≤5.2%
批间差:已知浓度的3个样本在不同的板子上重复测定5次,以评估测定批间精密度。
批间 CV: ≤6.5%
回收率
回收率:低、中和高浓度的分析物被掺入到血清或者血浆样本中,进行回收实验测定。

Sample Type

Average(%)

Recovery Range(%)

Serum

97

91-103

Plasma

99

93-105

 

 

 

 

线性
线性:给定样本通过梯度稀释,每次稀释的测量值与理论值的比值。

Sample

1:2

1:4

1:8

1:16

serum(n=5)

99-110%

99-108%

95-106%

108-118%

EDTA plasma(n=5)

86-96%

108-116%

98-109%

114-124%

heparin plasma(n=5)

109-120%

 

97-97%

88-96%

90-98%

 

通用注释


亚单元:
Monomer, homodimer, and homotetramer (PubMed:20952656). Can form filamentous polymers (PubMed:20457939, PubMed:20952656). Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation and inhibits lipid synthesis (PubMed:12360400, PubMed:16326698). Interacts with MID1IP1; interaction with MID1IP1 promotes oligomerization and increases its activity (PubMed:20457939).


功能:
Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA, a key metabolite in the fatty acid synthetic (PubMed:20952656, PubMed:20457939). Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase (PubMed:20952656, PubMed:20457939).


亚细胞位置:
Cytoplasm


该产品尚未在任何出版物中被引用。

[1].
"Acetyl-CoA carboxylase alpha gene and breast cancer susceptibility."

[2].
"Acetyl-coenzyme A carboxylase alpha gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels."

[3].
"Haplotype-based analysis of common variation in the acetyl-coA carboxylase alpha gene and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition."

[4].
"BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase."

[5].
"Asymmetric expression of transcripts derived from the shared promoter between the divergently oriented ACACA and TADA2L genes."

[6].
"Acetyl-CoA carboxylase alpha gene and breast cancer susceptibility."

[7].
"Acetyl-coenzyme A carboxylase alpha gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels."

[8].
"Haplotype-based analysis of common variation in the acetyl-coA carboxylase alpha gene and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition."

[9].
"BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase."

[10].
"Asymmetric expression of transcripts derived from the shared promoter between the divergently oriented ACACA and TADA2L genes."
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