ABRA (基因名), Actin-binding Rho-activating protein (蛋白名), ABRA_HUMAN.
Human ABRA/ Actin-binding Rho-activating protein ELISA Kit
Striated muscle activator of Rho-dependent signaling, STARS
Natural and recombinant human Actin-binding Rho-activating protein
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Binds F-actin and ABLIM1, ABLIM2 AND ABLIM3. Interaction with ABLIM2 AND ABLIM3 enhances activity.
Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling.
Cytoplasm Myofibril Sarcomere Cytoplasm Cytoskeleton Localized to the I-band of the sarcomere and to a lesser extent to the sarcomeric structure between Z-lines.
MAPGEKESGE | GPAKSALRKI | RTATLVISLA | RGWQQWANEN | SIRQAQEPTG |
WLPGGTQDSP | QAPKPITPPT | SHQKAQSAPK | SPPRLPEGHG | DGQSSEKAPE |
VSHIKKKEVS | KTVVSKTYER | GGDVSHLSHR | YERDAGVLEP | GQPENDIDRI |
LHSHGSPTRR | RKCANLVSEL | TKGWRVMEQE | EPTWRSDSVD | TEDSGYGGEA |
EERPEQDGVQ | VAVVRIKRPL | PSQVNRFTEK | LNCKAQQKYS | PVGNLKGRWQ |
QWADEHIQSQ | KLNPFSEEFD | YELAMSTRLH | KGDEGYGRPK | EGTKTAERAK |
RAEEHIYREM | MDMCFIICTM | ARHRRDGKIQ | VTFGDLFDRY | VRISDKVVGI |
LMRARKHGLV | DFEGEMLWQG | RDDHVVITLL | K
"STARS, a striated muscle activator of Rho signaling and serum response factor-dependent transcription."
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"Striated muscle activator of Rho signalling (STARS) is reduced in ageing human skeletal muscle and targeted by miR-628-5p."
"Identification of striated muscle activator of Rho signaling (STARS) as a novel calmodulin target by a newly developed genome-wide screen."
"Effect of resistance exercise contraction mode and protein supplementation on members of the STARS signalling pathway."
"Genome-wide association scan of dental caries in the permanent dentition."
"Striated muscle activator of Rho signalling (STARS) is a PGC-1α/oestrogen-related receptor-α target gene and is upregulated in human skeletal muscle after endurance exercise."
"Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
"Regulation of STARS and its downstream targets suggest a novel pathway involved in human skeletal muscle hypertrophy and atrophy."
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