ABL2 (基因名), Tyrosine-protein kinase ABL2 (蛋白名), ABL2_HUMAN.
Human ABL2/ Tyrosine-protein kinase ABL2 ELISA Kit
Abelson murine leukemia viral oncogene homolog 2, ABLL, ARG, Abelson tyrosine-protein kinase 2, Abelson-related gene protein, Tyrosine-protein kinase ARG
Natural and recombinant human Tyrosine-protein kinase ABL2
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with PSMA7. Interacts with CTTN. Found in a complex with ABL1, ABL2, CRK and UNC119; leading to the inhibition of CRK phosphorylation by ABL kinases.
Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.
MGQQVGRVGE | APGLQQPQPR | GIRGSSAARP | SGRRRDPAGR | TTETGFNIFT |
QHDHFASCVE | DGFEGDKTG | GSSPEALHRP | YGCDVEPQAL | NEAIRWSSKE |
NLLGATESDP | NLFVALYDFV | A SGDNTLSI | TKGEKLRVLG | YNQNGEWSEV |
RSKNGQGWVP | SNYITPVNSL | EKHSWYHGPV | SR SAAEYLL | SSLINGSFLV |
RESESSPGQL | SISLRYEGRV | YHYRINTTAD | GKVYVTAESR | FST LAELVH |
HHSTVADGLV | TTLHYPAPKC | NKPTVYGVSP | IHDKWEMERT | DITMKHKLGG |
GQYG EVYVG | VWKKYSLTVA | VKTLKEDTME | VEEFLKEAAV | MKEIKHPNLV |
QLLGVCTLEP | PFYIV TEYM | PYGNLLDYLR | ECNREEVTAV | VLLYMATQIS |
SAMEYLEKKN | FIHRDLAARN | CLVGEN HVV | KVADFGLSRL | MTGDTYTAHA |
GAKFPIKWTA | PESLAYNTFS | IKSDVWAFGV | LLWEIAT YG | MSPYPGIDLS |
QVYDLLEKGY | RMEQPEGCPP | KVYELMRACW | KWSPADRPSF | AETHQAFE T |
MFHDSSISEE | VAEELGRAAS | SSSVVPYLPR | LPILPSKTRT | LKKQVENKEN |
IEGAQDATE | NSASSLAPGF | IRGAQASSGS | PALPRKQRDK | SPSSLLEDAK |
ETCFTRDRKG | GFFSSFMKKR | NAPTPPKRS | SSFREMENQP | HKKYELTGNF |
SSVASLQHAD | GFSFTPAQQE | ANLVPPKCYG | G SFAQRNLC | NDDGGGGGGS |
GTAGGGWSGI | TGFFTPRLIK | KTLGLRAGKP | TASDDTSKPF | PR SNSTSSM |
SSGLPEQDRM | AMTLPRNCQR | SKLQLERTVS | TSSQPEENVD | RANDMLPKKS |
EES AAPSRE | RPKAKLLPRG | ATALPLRTPS | GDLAITEKDP | PGVGVAGVAA |
APKGKEKNGG | ARLG MAGVP | EDGEQPGWPS | PAKAAPVLPT | THNHKVPVLI |
SPTLKHTPAD | VQLIGTDSQG | NKFKL LSEH | QVTSSGDKDR | PRRVKPKCAP |
PPPPVMRLLQ | HPSICSDPTE | EPTALTAGQS | TSETQE GGK | KAALGAVPIS |
GKAGRPVMPP | PQVPLPTSSI | SPAKMANGTA | GTKVALRKTK | QAAEKIS AD |
KISKEALLEC | ADLLSSALTE | PVPNSQLVDT | GHQLLDYCSG | YVDCIPQTRN |
KFAFREAV S | KLELSLQELQ | VSSAAAGVPG | TNPVLNNLLS | CVQEISDVVQ |
"Eight full-length abelson related gene (Arg) isoforms are constitutively expressed in caki-1 cell line and cell distribution of two isoforms has been analyzed after transfection."
"Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation."
"Ubiquitination and degradation of the Arg tyrosine kinase is regulated by oxidative stress."
"A novel human gene closely related to the abl proto-oncogene."
"A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order."
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."
"Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study."
"ABL tyrosine kinases: evolution of function, regulation, and specificity."
"Reciprocal regulation of Abl and receptor tyrosine kinases."
"A critical role for cortactin phosphorylation by Abl-family kinases in PDGF-induced dorsal-wave formation."
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