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首页  >  酶联免疫试剂盒  >  Mouse Abi2 ELISA Kit
Abi2 (基因名), Abl interactor 2 (蛋白名), ABI2_MOUSE.
产品名称:

Mouse Abi2/ Abl interactor 2 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Abelson interactor 2, Abi-2, Abl-binding protein 3, AblBP3, Arg-binding protein 1, ArgBP1

检测方法:
ELISA
特异性:
Natural and recombinant mouse Abl interactor 2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Mouse Abi2 ELISA Kit
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Mouse Abi2 ELISA Kit
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产品说明书


通用注释


亚单元:
Component of the WAVE complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterodimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WASF1/WAVE1, ABI2 and BRK1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1 (By similarity). Interacts (via SH3 domain) with ABL1 and ABL2 (By similarity).


功能:
Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (By similarity). Acts as regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (By similarity). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (PubMed:15572692). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (PubMed:27605705). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (PubMed:15572692). Also required for nascent adherens junction assembly in epithelial cells (By similarity).


亚细胞位置:
Cell projection Lamellipodium Cell projection Filopodium Cytoplasm Cytoskeleton Cell junction Adherens junction Cell projection Dendritic spine Localized to the protruding lamellipodia and filopodia tips (By similarity). Present at nascent adherens junctions where it clusters adjacent to the tips of F-actin protrusions (By similarity).


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