Abi2 (基因名), Abl interactor 2 (蛋白名), ABI2_MOUSE.
Mouse Abi2/ Abl interactor 2 ELISA Kit
Abelson interactor 2, Abi-2, Abl-binding protein 3, AblBP3, Arg-binding protein 1, ArgBP1
Natural and recombinant mouse Abl interactor 2
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Component of the WAVE complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterodimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WASF1/WAVE1, ABI2 and BRK1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1 (By similarity). Interacts (via SH3 domain) with ABL1 and ABL2 (By similarity).
Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (By similarity). Acts as regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (By similarity). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (PubMed:15572692). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (PubMed:27605705). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (PubMed:15572692). Also required for nascent adherens junction assembly in epithelial cells (By similarity).
Cell projection Lamellipodium Cell projection Filopodium Cytoplasm Cytoskeleton Cell junction Adherens junction Cell projection Dendritic spine Localized to the protruding lamellipodia and filopodia tips (By similarity). Present at nascent adherens junctions where it clusters adjacent to the tips of F-actin protrusions (By similarity).
MAELQMLLEE | EIPGGRRALF | DSYTNLERVA | DYCENNYIQS | PDKQRALEET |
KAYTTQSLAS | VAYLINTLA | NNVLQMLDIQ | ASQLRRMESS | INHISQTVDI |
HKEKVARREI | GILTTNKNTS | R THKIIAPA | NLERPVRYIR | KPIDYTILDD |
IGHGVKVSTQ | NMKMGGLPRT | TPPTQKPPSP | PM SGKGTLG | RHSPYRTLEP |
VRPPVVPNDY | VPSPTRNMAP | SQQSPVRTAS | VNQRNRTYSS | SGS SGGSHP |
SSRSSSRENS | GSGSVGVPIA | VPTPSPPSVF | PGHPVQFYSM | NRPASRHTPP |
TIGG SLPYR | RPPSITSQTS | LQNQMNGGPF | YNQNPVSDTP | PPPPPVEEPV |
FDESPPPPPP | PEDYE EEEA | AVVEYSDPYA | EEDPPWAPRA | YLEKVVAIYD |
YTKDKEDELS | FQEGAIIYVI | KKNDDG WYE | GVMNGVTGLF | PGNYVESIMH |
"Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity."
"Identification of ArgBP1, an Arg protein tyrosine kinase binding protein that is the human homologue of a CNS-specific Xenopus gene."
"GWAS of butyrylcholinesterase activity identifies four novel loci, independent effects within BCHE and secondary associations with metabolic risk factors."
"Structure and control of the actin regulatory WAVE complex."
"Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study."
"The expression of Abl interactor 2 in leiomyoma and myometrium and regulation by GnRH analogue and transforming growth factor-beta."
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"Screen and identification of proteins interacting with ADAM19 cytoplasmic tail."
"The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia."
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