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首页  >  酶联免疫试剂盒  >  Human ABI2 ELISA Kit
ABI2 (基因名), Abl interactor 2 (蛋白名), ABI2_HUMAN.
产品名称:

Human ABI2/ Abl interactor 2 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Abelson interactor 2, Abi-2, Abl-binding protein 3, AblBP3, Arg-binding protein 1, ArgBP1, ARGBPIA

检测方法:
ELISA
特异性:
Natural and recombinant human Abl interactor 2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Human ABI2 ELISA Kit
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Human ABI2 ELISA Kit
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产品说明书


通用注释


亚单元:
Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterodimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1 (By similarity). Interacts with ABL1 and ABL2. Interacts with human cytomegalovirus UL135.


功能:
May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes.


亚细胞位置:
Isoform 1 Cell projection Lamellipodium Cell projection Filopodium Cytoplasm Cytoskeleton Isoform 1 but not isoform 3 is localized to protruding lamellipodia and filopodia tips.


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