ABI2 (GeneName), Abl interactor 2 (ProteinName), ABI2_HUMAN.
Human ABI2/ Abl interactor 2 ELISA Kit
Abelson interactor 2, Abi-2, Abl-binding protein 3, AblBP3, Arg-binding protein 1, ArgBP1, ARGBPIA
Natural and recombinant human Abl interactor 2
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterodimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1 (By similarity). Interacts with ABL1 and ABL2. Interacts with human cytomegalovirus UL135.
May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes.
Isoform 1 Cell projection Lamellipodium Cell projection Filopodium Cytoplasm Cytoskeleton Isoform 1 but not isoform 3 is localized to protruding lamellipodia and filopodia tips.
MAELQMLLEE | EIPGGRRALF | DSYTNLERVA | DYCENNYIQS | ADKQRALEET |
KAYTTQSLAS | VAYLINTLAN | NVLQMLDIQA | SQLRRMESSI | NHISQTVDIH |
KEKVARREIG | ILTTNKNTSR | THKIIAPANL | ERPVRYIRKP | IDYTILDDIG |
HGVKWLLRFK | VSTQNMKMGG | LPRTTPPTQK | PPSPPMSGKG | TLGRHSPYRT |
LEPVRPPVVP | NDYVPSPTRN | MAPSQQSPVR | TASVNQRNRT | YSSSGSSGGS |
HPSSRSSSRE | NSGSGSVGVP | IAVPTPSPPS | VFPAPAGSAG | TPPLPATSAS |
APAPLVPATV | PSSTAPNAAA | GGAPNLADGF | TSPTPPVVSS | TPPTGHPVQF |
YSMNRPASRH | TPPTIGGSLP | YRRPPSITSQ | TSLQNQMNGG | PFYSQNPVSD |
TPPPPPPVEE | PVFDESPPPP | PPPEDYEEEE | AAVVEYSDPY | AEEDPPWAPR |
SYLEKVVAIY | DYTKDKEDEL | SFQEGAIIYV | IKKNDDGWYE | GVMNGVTGLF |
PGNYVESIMH | YSE
This product has not yet been referenced specifically in any publications.
"Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity."
"Identification of ArgBP1, an Arg protein tyrosine kinase binding protein that is the human homologue of a CNS-specific Xenopus gene."
"GWAS of butyrylcholinesterase activity identifies four novel loci, independent effects within BCHE and secondary associations with metabolic risk factors."
"Structure and control of the actin regulatory WAVE complex."
"Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study."
"The expression of Abl interactor 2 in leiomyoma and myometrium and regulation by GnRH analogue and transforming growth factor-beta."
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"Screen and identification of proteins interacting with ADAM19 cytoplasmic tail."
"The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia."
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