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首页  >  酶联免疫试剂盒  >  Rat Abi1 ELISA Kit
Abi1 (基因名), Abl interactor 1 (蛋白名), ABI1_RAT.
产品名称:

Rat Abi1/ Abl interactor 1 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Abelson interactor 1, Abi-1, Eps8 SH3 domain-binding protein, Eps8-binding protein, e3B1

检测方法:
ELISA
特异性:
Natural and recombinant rat Abl interactor 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Rat Abi1 ELISA Kit
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Rat Abi1 ELISA Kit
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产品说明书


通用注释


亚单元:
Interacts with ABL1, ENAH, STX1A, SNAP25, VAMP2, EPS8, SOS1, SOS2, GRB2, SPTA1, NCKAP1/NAP1, the first SH3 domain of NCK1 and through its N-terminus with WASF1. Part of a complex consisting of ABI1, STX1A and SNAP25. Part of a complex consisting of ABI1, EPS8 and SOS1. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 (NCKAP1l/HEM1 in hematopoietic cells) and WASF2/WAVE2. Interacts (via SH3 domain) with SHANK2 and SHANK3, but not SHANK1; the interaction is direct. Interacts with the heterodimer MYC:MAX; the interaction may enhance MYC:MAX transcriptional activity. Interacts with FNBP1L (via the SH3 domain), WASF2, and CDC42, but only in the presence of FNBP1L.


功能:
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.


亚细胞位置:
Cytoplasm Nucleus Cell projection Lamellipodium Cell projection Filopodium Cell projection Growth cone Cell junction Synapse Postsynaptic cell membrane Postsynaptic density Cytoplasm Cytoskeleton Localized to protruding lamellipodia and filopodia tips. May shuttle from the postsynaptic densities to the nucleus.


该产品尚未在任何出版物中被引用。

[1].
"Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth."

[2].
"Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease."

[3].
"Abl interactor 1 binds to sos and inhibits epidermal growth factor- and v-Abl-induced activation of extracellular signal-regulated kinases."

[4].
"Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton."

[5].
"ABI-1, a human homolog to mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10;11)(p11.2;q23)."

[6].
"Abl interactor 1 regulates Src-Id1-matrix metalloproteinase 9 axis and is required for invadopodia formation, extracellular matrix degradation and tumor growth of human breast cancer cells."

[7].
"Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis."

[8].
"Allosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1."

[9].
"Abelson interactor protein-1 positively regulates breast cancer cell proliferation, migration, and invasion."

[10].
"A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease."
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