Abi1 (基因名), Abl interactor 1 (蛋白名), ABI1_MOUSE.
Mouse Abi1/ Abl interactor 1 ELISA Kit
Abelson interactor 1, Abi-1, Ablphilin-1, Eps8 SH3 domain-binding protein, Eps8-binding protein, Spectrin SH3 domain-binding protein 1, e3B1, Ssh3bp1
Natural and recombinant mouse Abl interactor 1
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with ENAH, Abelson murine leukemia virus V-ABL, ABL1, STX1A, SNAP25, VAMP2, and through its N-terminus with WASF1. Part of a complex consisting of ABI1, STX1A and SNAP25. Part of a complex consisting of ABI1, EPS8 and SOS1. Interacts with EPS8, SOS1, SOS2, GRB2, SPTA1, and the first SH3 domain of NCK1 (By similarity). Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 (NCKAP1l/HEM1 in hematopoietic cells) and WASF2/WAVE2. Interacts (via SH3 domain) with SHANK2 and SHANK3, but not SHANK1; the interaction is direct. Interacts with the heterodimer MYC:MAX; the interaction may enhance MYC:MAX transcriptional activity. Interacts with FNBP1L (via the SH3 domain), WASF2, and CDC42, but only in the presence of FNBP1L.
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. In vitro, at least isoform 2 and isoform 4 suppress the transforming activity of Abelson murine leukemia virus (v-Abl) after overexpression in fibroblasts. May play a role in regulation EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.
Cytoplasm Nucleus Cell projection Lamellipodium Cell projection Filopodium Cell projection Growth cone Cell junction Synapse Postsynaptic cell membrane Postsynaptic density Cytoplasm Cytoskeleton Localized to protruding lamellipodia and filopodia tips. Also localized to neuronal growth cones and synaptosomes. May shuttle from the postsynaptic densities to the nucleus (By similarity).
MAELQMLLEE | EIPSGKRALI | ESYQNLTRVA | DYCENNYIQA | TDKRKALEET |
KAYTTQSLAS | VAYQINALAN | NVLQLLDIQA | SQLRRMESSI | NHISQTVDIH |
KEKVARREIG | ILTTNKNTSR | THKIIAPANM | ERPVRYIRKP | IDYTVLDDVG |
HGVKWLKAKH | GNNQPARTGT | LSRTNPPTQK | PPSPPVSGRG | TLGRNTPYKT |
LEPVKPPTVP | NDYMTSPARL | GSQHSPGRTA | SLNQRPRTHS | GSSGGSGSRE |
NSGSSSIGIP | IAVPTPSPPT | AGPAAPGAAP | GSQYGTMTRQ | ISRHNSTTSS |
TSSGGYRRTP | SVAAQFSAQP | HVNGGPLYSQ | NSISVAPPPP | PMPQLTPQIP |
LTGFVARVQE | NIADSPTPPP | PPPPDDIPMF | DDSPPPPPPP | PVDYEDEEAA |
VVQYSDPYAD | GDPAWAPKNY | IEKVVAIYDY | TKDKDDELSF | KEGAIIYVIK |
KNDDGWFEGV | CNRVTGLFPG | NYVESIMHYT | D
"Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth."
"Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease."
"Abl interactor 1 binds to sos and inhibits epidermal growth factor- and v-Abl-induced activation of extracellular signal-regulated kinases."
"Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton."
"ABI-1, a human homolog to mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10;11)(p11.2;q23)."
"Abl interactor 1 regulates Src-Id1-matrix metalloproteinase 9 axis and is required for invadopodia formation, extracellular matrix degradation and tumor growth of human breast cancer cells."
"Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis."
"Allosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1."
"Abelson interactor protein-1 positively regulates breast cancer cell proliferation, migration, and invasion."
"A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease."
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