ABHD5 (GeneName), 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (ProteinName), ABHD5_PIG.
Pig ABHD5/ 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 ELISA Kit
Abhydrolase domain-containing protein 5
Natural and recombinant pig 1-acylglycerol-3-phosphate O-acyltransferase ABHD5
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with ADRP, PLIN and PNPLA2. Interacts with PLIN5; promotes interaction with PNPLA2.
Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. Regulates lipid droplet fusion.
Cytoplasm Lipid droplet Colocalized with PLIN and ADRP on the surface of lipid droplets. The localization is dependent upon the metabolic status of the adipocytes and the activity of PKA (By similarity).
MAAEEEEMDS | TDACERSGWL | TGWLPTWCPT | STSHLKEAEE | KILKCVPCIY |
KKGPVRISNG | NKIWTLKLSH | NISNKIPLVL | LHGFGGGLGL | WALNFGDLCT |
NRPVYAFDLL | GFGRSSRPRF | DTDAEEVENQ | FVESIEEWRC | ALGLDKVILL |
GHNLGGFLAA | AYSLKYPSRV | SHLILVEPWG | FPERPDLADQ | ERPIPVWIRA |
LGAALTPFNP | LAGLRIAGPF | GLSLVQRLRP | DFKRKYSSMF | EDDTVTEYIY |
HCNVQTPSGE | TAFKNMTIPY | GWAKRPMLHR | IGKMNPDIPV | SVIYGARSCI |
DGNSGTSIQS | LRPHSYVKTI | AILGAGHYVY | ADQPEDFNLK | VKEICDTVD
This product has not yet been referenced specifically in any publications.
"Mutations in CGI-58, the gene encoding a new protein of the esterase/lipase/thioesterase subfamily, in Chanarin-Dorfman syndrome."
"CGI-58, the causative gene for Chanarin-Dorfman syndrome, mediates acylation of lysophosphatidic acid."
"CGI-58 is an alpha/beta-hydrolase within lipid transporting lamellar granules of differentiated keratinocytes."
"Two new mutations of the ABHD5 gene in a new adult case of Chanarin Dorfman syndrome: an uncommon lipid storage disease."
"Molecular analysis of Chanarin-Dorfman syndrome (CDS) patients: Identification of novel mutations in the ABHD5 gene."
"High frequency of ETFDH c.250G>A mutation in Taiwanese patients with late-onset lipid storage myopathy."
"Chanarin-Dorfman syndrome: deficiency in CGI-58, a lipid droplet-bound coactivator of lipase."
"Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase/PNPLA2 or CGI-58/ABHD5."
"Analysis of lipolytic protein trafficking and interactions in adipocytes."
"A novel S115G mutation of CGI-58 in a Turkish patient with Dorfman-Chanarin syndrome."
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