ABHD4 (GeneName), (Lyso)-N-acylphosphatidylethanolamine lipase (ProteinName), ABHD4_HUMAN.
Human ABHD4/ (Lyso)-N-acylphosphatidylethanolamine lipase ELISA Kit
Alpha/beta hydrolase domain-containing protein 4, Abhydrolase domain-containing protein 4, Alpha/beta-hydrolase 4
Natural and recombinant human (Lyso)-N-acylphosphatidylethanolamine lipase
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine.
MADDLEQQSQ | GWLSSWLPTW | RPTSMSQLKN | VEARILQCLQ | NKFLARYVSL |
PNQNKIWTVT | VSPEQNDRT | PLVMVHGFGG | GVGLWILNMD | SLSARRTLHT |
FDLLGFGRSS | RPAFPRDPEG | A EDEFVTSI | ETWRETMGIP | SMILLGHSLG |
GFLATSYSIK | YPDRVKHLIL | VDPWGFPLRP | TN PSEIRAP | PAWVKAVASV |
LGRSNPLAVL | RVAGPWGPGL | VQRFRPDFKR | KFADFFEDDT | ISE YIYHCN |
AQNPSGETAF | KAMMESFGWA | RRPMLERIHL | IRKDVPITMI | YGSDTWIDTS |
TGKK VKMQR | PDSYVRDMEI | KGASHHVYAD | QPHIFNAVVE | EICDSVD
This product has not yet been referenced specifically in any publications.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"A genome wide shRNA screen identifies α/β hydrolase domain containing 4 (ABHD4) as a novel regulator of anoikis resistance."
"Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
"A directed protein interaction network for investigating intracellular signal transduction."
"Toward a confocal subcellular atlas of the human proteome."
"A shifted repertoire of endocannabinoid genes in the zebrafish (Danio rerio)."
"Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathway."
"The DNA sequence and analysis of human chromosome 14."
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."
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