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ABHD2 (GeneName), Monoacylglycerol lipase ABHD2 (ProteinName), ABHD2_HUMAN.
Product Name:

Human ABHD2/ Monoacylglycerol lipase ABHD2 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

2-arachidonoylglycerol hydrolase, Abhydrolase domain-containing protein 2, LABH2, Acetylesterase, Lung alpha/beta hydrolase 2, Progesterone-sensitive lipase, Protein PHPS1-2

Detection Method:
ELISA
Specificity:
Natural and recombinant human Monoacylglycerol lipase ABHD2
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Human ABHD2 ELISA Kit
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Human ABHD2 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
N/A


Function:
Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane (PubMed:26989199). Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) (PubMed:26989199). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester (PubMed:27247428). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (PubMed:26989199). May also play a role in smooth muscle cells migration (By similarity).


Subcellular Location:
Cell projection Cilium Flagellum membrane Single-pass type II membrane protein Cell membrane Single-pass type II membrane protein


This product has not yet been referenced specifically in any publications.

[1].
"Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone."

[2].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[3].
"Primary structure of a human protein which bears structural similarities to members of the rhodopsin/beta-adrenergic receptor family."

[4].
"Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing."

[5].
"Joint Analysis of Nuclear and Mitochondrial Variants in Age-Related Macular Degeneration Identifies Novel Loci TRPM1 and ABHD2/RLBP1."

[6].
"Molecular characterization of human ABHD2 as TAG lipase and ester hydrolase."

[7].
"Suppression of ABHD2, identified through a functional genomics screen, causes anoikis resistance, chemoresistance and poor prognosis in ovarian cancer."

[8].
"Associations of ABHD2 genetic variations with risks for chronic obstructive pulmonary disease in a Chinese Han population."

[9].
"Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population."

[10].
"Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
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