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ABHD12 (GeneName), Lysophosphatidylserine lipase ABHD12 (ProteinName), ABD12_HUMAN.
Product Name:

Human ABHD12/ Lysophosphatidylserine lipase ABHD12 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Abhydrolase domain-containing protein 12, C20orf22, 2-arachidonoylglycerol hydrolase ABHD12, hABHD12, Monoacylglycerol lipase ABHD12, Oxidized phosphatidylserine lipase ABHD12

Detection Method:
ELISA
Specificity:
Natural and recombinant human Lysophosphatidylserine lipase ABHD12
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Human ABHD12 ELISA Kit
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Human ABHD12 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
N/A


Function:
Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (PubMed:25290914, PubMed:30237167, PubMed:30420694, PubMed:30720278, PubMed:30643283). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal (PubMed:30643283). Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways (PubMed:22969151, PubMed:24027063). Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (PubMed:30237167).


Subcellular Location:
Endoplasmic reticulum membrane Single-pass membrane protein


This product has not yet been referenced specifically in any publications.

[1].
"Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12)."

[2].
"Biochemical and pharmacological characterization of the human lymphocyte antigen B-associated transcript 5 (BAT5/ABHD16A)."

[3].
"Two novel mutations in ABHD12: expansion of the mutation spectrum in PHARC and assessment of their functional effects."

[4].
"Targeted next-generation sequencing identifies a homozygous nonsense mutation in ABHD12, the gene underlying PHARC, in a family clinically diagnosed with Usher syndrome type 3."

[5].
"Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma."
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