ABHD12 (GeneName), Lysophosphatidylserine lipase ABHD12 (ProteinName), ABD12_BOVIN.
Product Name:
Bovine ABHD12/ Lysophosphatidylserine lipase ABHD12 ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
Abhydrolase domain-containing protein 12, 2-arachidonoylglycerol hydrolase ABHD12, Monoacylglycerol lipase ABHD12, Oxidized phosphatidylserine lipase ABHD12
Detection Method:
ELISA
Specificity:
Natural and recombinant bovine Lysophosphatidylserine lipase ABHD12
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
N/A
Function:
Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (By similarity). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways. Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (By similarity).
Subcellular Location:
Endoplasmic reticulum membrane
Single-pass membrane protein
Database link
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12)."
[2].
"Biochemical and pharmacological characterization of the human lymphocyte antigen B-associated transcript 5 (BAT5/ABHD16A)."
[3].
"Two novel mutations in ABHD12: expansion of the mutation spectrum in PHARC and assessment of their functional effects."
[4].
"Targeted next-generation sequencing identifies a homozygous nonsense mutation in ABHD12, the gene underlying PHARC, in a family clinically diagnosed with Usher syndrome type 3."
[5].
"Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma."
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