ABCG8 (GeneName), ATP-binding cassette sub-family G member 8 (ProteinName), ABCG8_HUMAN.
Human ABCG8/ ATP-binding cassette sub-family G member 8 ELISA Kit
Natural and recombinant human ATP-binding cassette sub-family G member 8
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
May form heterodimers with ABCG5 or be tightly coupled to ABCG5 along a pathway regulating diatery-sterol absorption and excretion.
Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.
Membrane Multi-pass membrane protein
MAGKAAEERG | LPKGATPQDT | SGLQDRLFSS | ESDNSLYFTY | SGQPNTLEVR |
DLNYQVDLAS | QVPWFEQLAQ | FKMPWTSPSC | QNSCELGIQN | LSFKVRSGQM |
LAIIGSSGCG | RASLLDVITG | RGHGGKIKSG | QIWINGQPSS | PQLVRKCVAH |
VRQHNQLLPN | LTVRETLAFI | AQMRLPRTFS | QAQRDKRVED | VIAELRLRQC |
ADTRVGNMYV | RGLSGGERRR | VSIGVQLLWN | PGILILDEPT | SGLDSFTAHN |
LVKTLSRLAK | GNRLVLISLH | QPRSDIFRLF | DLVLLMTSGT | PIYLGAAQHM |
VQYFTAIGYP | CPRYSNPADF | YVDLTSIDRR | SREQELATRE | KAQSLAALFL |
EKVRDLDDFL | WKAETKDLDE | DTCVESSVTP | LDTNCLPSPT | KMPGAVQQFT |
TLIRRQISND | FRDLPTLLIH | GAEACLMSMT | IGFLYFGHGS | IQLSFMDTAA |
LLFMIGALIP | FNVILDVISK | CYSERAMLYY | ELEDGLYTTG | PYFFAKILGE |
LPEHCAYIII | YGMPTYWLAN | LRPGLQPFLL | HFLLVWLVVF | CCRIMALAAA |
ALLPTFHMAS | FFSNALYNSF | YLAGGFMINL | SSLWTVPAWI | SKVSFLRWCF |
EGLMKIQFSR | RTYKMPLGNL | TIAVSGDKIL | SVMELDSYPL | YAIYLIVIGL |
SGGFMVLYYV | SLRFIKQKPS | QDW
This product has not yet been referenced specifically in any publications.
"Increased gallstone risk in humans conferred by common variant of hepatic ATP-binding cassette transporter for cholesterol."
"Genetic variations at ABCG5/G8 genes modulate plasma lipids concentrations in patients with familial hypercholesterolemia."
"Common sequence variants in pharmacodynamic and pharmacokinetic pathway-related genes conferring LDL cholesterol response to statins."
"ABCG8 gene polymorphisms, plasma cholesterol concentrations, and risk of cardiovascular disease in familial hypercholesterolemia."
"Long-term consumption of plant stanol and sterol esters, vascular function and genetic regulation."
"The metabolism of plant sterols is disturbed in postmenopausal women with coronary artery disease."
"Significant association of ABCG5 604Q and ABCG8 D19H polymorphisms with gallstone disease."
"Significant association of ABCG8:D19H gene polymorphism with hypercholesterolemia and insulin resistance."
"Association between non-responsiveness to plant sterol intervention and polymorphisms in cholesterol metabolism genes: a case-control study."
"Single nucleotide polymorphisms in ABCG5 and ABCG8 genes in Chilean subjects with polygenic hypercholesterolemia and controls."
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