ABCG5 (GeneName), ATP-binding cassette sub-family G member 5 (ProteinName), ABCG5_HUMAN.
Human ABCG5/ ATP-binding cassette sub-family G member 5 ELISA Kit
Natural and recombinant human ATP-binding cassette sub-family G member 5
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
May form heterodimers with ABCG8 or be tightly coupled to ABCG8 along a pathway regulating diatery-sterol absorption and excretion.
Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.
Membrane Multi-pass membrane protein
MGDLSSLTPG | GSMGLQVNRG | SQSSLEGAPA | TAPEPHSLGI | LHASYSVSHR |
VRPWWDITSC | RQQWTRQILK | DVSLYVESGQ | IMCILGSSGS | GKTTLLDAMS |
GRLGRAGTFL | GEVYVNGRAL | RREQFQDCFS | YVLQSDTLLS | SLTVRETLHY |
TALLAIRRGN | PGSFQKKVEA | VMAELSLSHV | ADRLIGNYSL | GGISTGERRR |
VSIAAQLLQD | PKVMLFDEPT | TGLDCMTANQ | IVVLLVELAR | RNRIVVLTIH |
QPRSELFQLF | DKIAILSFGE | LIFCGTPAEM | LDFFNDCGYP | CPEHSNPFDF |
YMDLTSVDTQ | SKEREIETSK | RVQMIESAYK | KSAICHKTLK | NIERMKHLKT |
LPMVPFKTKD | SPGVFSKLGV | LLRRVTRNLV | RNKLAVITRL | LQNLIMGLFL |
LFFVLRVRSN | VLKGAIQDRV | GLLYQFVGAT | PYTGMLNAVN | LFPVLRAVSD |
QESQDGLYQK | WQMMLAYALH | VLPFSVVATM | IFSSVCYWTL | GLHPEVARFG |
YFSAALLAPH | LIGEFLTLVL | LGIVQNPNIV | NSVVALLSIA | GVLVGSGFLR |
NIQEMPIPFK | IISYFTFQKY | CSEILVVNEF | YGLNFTCGSS | NVSVTTNPMC |
AFTQGIQFIE | KTCPGATSRF | TMNFLILYSF | IPALVILGIV | VFKIRDHLIS |
This product has not yet been referenced specifically in any publications.
"Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively."
"The metabolism of plant sterols is disturbed in postmenopausal women with coronary artery disease."
"Long-term consumption of plant stanol and sterol esters, vascular function and genetic regulation."
"Significant association of ABCG5 604Q and ABCG8 D19H polymorphisms with gallstone disease."
"Single nucleotide polymorphisms in ABCG5 and ABCG8 genes in Chilean subjects with polygenic hypercholesterolemia and controls."
"Association between non-responsiveness to plant sterol intervention and polymorphisms in cholesterol metabolism genes: a case-control study."
"Significant association of ABCG8:D19H gene polymorphism with hypercholesterolemia and insulin resistance."
"Single nucleotide polymorphisms in ABCG5 and ABCG8 are associated with changes in cholesterol metabolism during weight loss."
"ATP binding cassette G8 T400K polymorphism may affect the risk of gallstone disease among Chinese males."
"Purification and ATP hydrolysis of the putative cholesterol transporters ABCG5 and ABCG8."
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