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ABCG2 (GeneName), ATP-binding cassette sub-family G member 2 (ProteinName), ABCG2_HUMAN.
Product Name:

Human ABCG2/ ATP-binding cassette sub-family G member 2 ELISA Kit

Cat.#:

E0960h

Brand:
EIAab®
Regulatory Status:
Alternative:

Breast cancer resistance protein, CDw338, Mitoxantrone resistance-associated protein, Placenta-specific ATP-binding cassette transporter, Urate exporter, CD338, ABCP, BCRP, BCRP1, MXR

Detection Method:
ELISA
Assay Type:
Sandwich
Detection Range:
0.156-10ng/mL
Sensitivity:
0.067ng/mL
Specificity:
Natural and recombinant human ATP-binding cassette sub-family G member 2
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Assay Procedure:
Assay Procedure
Research Area:
Neurosciences
Human ABCG2 ELISA Kit
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Human ABCG2 ELISA Kit
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Product Datasheets
Instruction: Down Instruction
MSDS: MSDS


Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤3.8%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤7.2%

Recovery
Recovery was determined by spiking various levels of ATP-binding cassette sub-family G member 2 into serum and plasma.

Sample Type

Average(%)

Recovery Range(%)

Serum

107

101-113

Plasma

109

103-115

 

 

 

 

Linearity
The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ATP-binding cassette sub-family G member 2 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample

1:2

1:4

1:8

1:16

serum(n=5)

80-89%

80-90%

107-117%

105-115%

EDTA plasma(n=5)

108-117%

89-99%

102-114%

99-108%

heparin plasma(n=5)

91-101%

 

98-108%

82-91%

85-97%

 

General Annotation


Sub Unit:
Monomer under reducing conditions, the minimal functional units is a homodimer; disulfide-linked, but the major oligomeric form in plasma membranes is a homotetramer with possibility of higher order oligomerization up to homododecamers.


Function:
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.


Subcellular Location:
Cell membrane Multi-pass membrane protein Mitochondrion membrane Multi-pass membrane protein


This product has not yet been referenced specifically in any publications.

[1].
"Breast cancer resistance protein and P-glycoprotein limit sorafenib brain accumulation."

[2].
"ABCG2 polymorphism is associated with the low-density lipoprotein cholesterol response to rosuvastatin."

[3].
"Identification and functional characterization of breast cancer resistance protein in human bronchial epithelial cells (Calu-3)."

[4].
"Telmisartan pharmacokinetics in Japanese renal transplant recipients."

[5].
"Sensitization of ABCG2-overexpressing cells to conventional chemotherapeutic agent by sunitinib was associated with inhibiting the function of ABCG2."
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