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ABCG1 (GeneName), ATP-binding cassette sub-family G member 1 (ProteinName), ABCG1_HUMAN.
Product Name:

Human ABCG1/ ATP-binding cassette sub-family G member 1 ELISA Kit

Cat.#:

E9149h

Brand:
EIAab®
Regulatory Status:
Alternative:

ATP-binding cassette transporter 8, White protein homolog, ABC8, WHT1

Detection Method:
ELISA
Assay Type:
Sandwich
Detection Range:
0.156-10ng/mL
Sensitivity:
0.075ng/mL
Specificity:
Natural and recombinant human ATP-binding cassette sub-family G member 1
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Assay Procedure:
Assay Procedure
Research Area:
Cardiovascular
Human ABCG1 ELISA Kit
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Human ABCG1 ELISA Kit
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Product Datasheets
Instruction: Down Instruction
MSDS: MSDS


Linearity
The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ATP-binding cassette sub-family G member 1 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample

1:2

1:4

1:8

1:16

serum(n=5)

102-113%

84-93%

103-112%

83-92%

EDTA plasma(n=5)

105-115%

106-115%

110-120%

97-107%

heparin plasma(n=5)

103-113%

 

90-100%

108-119%

103-116%

 

General Annotation


Sub Unit:
May form heterodimers with several heterologous partners of the ABCG subfamily.


Function:
Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages.


Subcellular Location:
Endoplasmic reticulum membrane Multi-pass membrane protein Golgi apparatus membrane Multi-pass membrane protein Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes.


This product has not yet been referenced specifically in any publications.

[1].
"Genotypic Effect of ABCG1 gene promoter -257T>G polymorphism on coronary artery disease severity in Japanese men."

[2].
"ABCG1 gene variants in suicidal behavior and aggression-related traits."

[3].
"Expression and functional characterization of ABCG1 splice variant ABCG1(666)."

[4].
"The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux."

[5].
"Expression of the ATP-binding cassette transporter gene ABCG1 (ABC8) in Tangier disease."

[6].
"Role of ABCG1 and other ABCG family members in lipid metabolism."

[7].
"Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein."

[8].
"Genomic sequence and structure of the human ABCG1 (ABC8) gene."

[9].
"ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport."

[10].
"Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols."
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