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ABCF1 (GeneName), ATP-binding cassette sub-family F member 1 (ProteinName), ABCF1_HUMAN.

Product Name:

Human ABCF1/ ATP-binding cassette sub-family F member 1 ELISA Kit

Cat.#:

Brand:

EIAab^®

Regulatory Status:

RUO

Alternative:

ATP-binding cassette 50, TNF-alpha-stimulated ABC protein, ABC50

Detection Method:

ELISA

Specificity:

Natural and recombinant human ATP-binding cassette sub-family F member 1

Sample Type:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Sample Data:

Research Area:

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Human ABCF1 ELISA Kit

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Product Datasheets

Data
Citations
Publication
Sequence / 3D
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General Annotation

Sub Unit:

Isoform 2 interacts (via N-terminus) with EIF2S1; the interaction is independent of its phosphorylated status. Isoform 2 associates (via both ABC transporter domains) with the ribosomes.

Function:

Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis.

Subcellular Location:

Isoform 2 Cytoplasm Nucleus Nucleoplasm Nucleus envelope

Database link

UniGene:

Hs.655285

STRING:

9606.ENSP00000313603

KEGG:

hsa:23

MIM:

603429

Pfam:

PF00005

Uniprot:

Q8NE71

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Sequence length:

845

Sequence:

50:

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800:

845:

LITETNCQLW | VVEEQSVSQI | DGDFEDYKRE | VLEALGEVMV | SRPRE

3D Structure:

Predicted Epitope:

Valid Sequence:

This product has not yet been referenced specifically in any publications.

[1].

"The N-terminal region of ABC50 interacts with eukaryotic initiation factor eIF2 and is a target for regulatory phosphorylation by CK2."

(PMID: 17894550)

[2].

"ABC50, a novel human ATP-binding cassette protein found in tumor necrosis factor-alpha-stimulated synoviocytes."

(PMID: 9790762)

[3].

"Identification of independent risk loci for Graves' disease within the MHC in the Japanese population."

(PMID: 21900946)

[4].

"Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects."

(PMID: 19343046)

[5].

"ABC50 promotes translation initiation in mammalian cells."

(PMID: 19570978)

[6].

"High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions."

(PMID: 19851445)

[7].

"HLA-E gene polymorphism associates with ankylosing spondylitis in Sardinia."

(PMID: 19912639)

[8].

"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."

(PMID: 16964243)

[9].

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."

(PMID: 17081983)

[10].

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."