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ABCE1 (GeneName), ATP-binding cassette sub-family E member 1 (ProteinName), ABCE1_HUMAN.
Product Name:

Human ABCE1/ ATP-binding cassette sub-family E member 1 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

2'-5'-oligoadenylate-binding protein, HuHP68, RNase L inhibitor, Ribonuclease 4 inhibitor, RNS4I, RLI, RNASEL1, RNASELI, RNS4I, OK/SW-cl.40

Detection Method:
ELISA
Specificity:
Natural and recombinant human ATP-binding cassette sub-family E member 1
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Human ABCE1 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Probably heterodimerizes with RNASEL; this interaction inhibits the RNASEL. Associates with HIV-1 Vif and HIV-1, HIV-2 and SIV Gag proteins.


Function:
Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.


Subcellular Location:
Cytoplasm Mitochondrion Localized to clusters of virus formation at the plasma membrane.


This product has not yet been referenced specifically in any publications.

[1].
"Cloning and characterization of a RNAse L inhibitor. A new component of the interferon-regulated 2-5A pathway."

[2].
"Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects."

[3].
"RNASEL and RNASEL-inhibitor variation and prostate cancer risk in Afro-Caribbeans."

[4].
"Basic residues in the nucleocapsid domain of Gag are required for interaction of HIV-1 gag with ABCE1 (HP68), a cellular protein important for HIV-1 capsid assembly."

[5].
"ABCE1, a member of ATP-binding cassette transporter gene, encodes peptides capable of inducing HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes in colon cancer patients."

[6].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[7].
"Conservation of a stepwise, energy-sensitive pathway involving HP68 for assembly of primate lentivirus capsids in cells."

[8].
"Identification of a host protein essential for assembly of immature HIV-1 capsids."

[9].
"The 2-5A/RNase L/RNase L inhibitor (RLI) [correction of (RNI)] pathway regulates mitochondrial mRNAs stability in interferon alpha-treated H9 cells."

[10].
"RNase L inhibitor is induced during human immunodeficiency virus type 1 infection and down regulates the 2-5A/RNase L pathway in human T cells."
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