ABCE1 (基因名), ATP-binding cassette sub-family E member 1 (蛋白名), ABCE1_HUMAN.
Human ABCE1/ ATP-binding cassette sub-family E member 1 ELISA Kit
2'-5'-oligoadenylate-binding protein, HuHP68, RNase L inhibitor, Ribonuclease 4 inhibitor, RNS4I, RLI, RNASEL1, RNASELI, RNS4I, OK/SW-cl.40
Natural and recombinant human ATP-binding cassette sub-family E member 1
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Probably heterodimerizes with RNASEL; this interaction inhibits the RNASEL. Associates with HIV-1 Vif and HIV-1, HIV-2 and SIV Gag proteins.
Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.
Cytoplasm Mitochondrion Localized to clusters of virus formation at the plasma membrane.
MADKLTRIAI | VNHDKCKPKK | CRQECKKSCP | VVRMGKLCIE | VTPQSKIAWI |
SETLCIGCGI | CIKKCPFGAL | SIVNLPSNLE | KETTHRYCAN | AFKLHRLPIP |
RPGEVLGLVG | TNGIGKSTAL | KILAGKQKPN | LGKYDDPPDW | QEILTYFRGS |
ELQNYFTKIL | EDDLKAIIKP | QYVDQIPKAA | KGTVGSILDR | KDETKTQAIV |
CQQLDLTHLK | ERNVEDLSGG | ELQRFACAVV | CIQKADIFMF | DEPSSYLDVK |
QRLKAAITIR | SLINPDRYII | VVEHDLSVLD | YLSDFICCLY | GVPSAYGVVT |
MPFSVREGIN | IFLDGYVPTE | NLRFRDASLV | FKVAETANEE | EVKKMCMYKY |
PGMKKKMGEF | ELAIVAGEFT | DSEIMVMLGE | NGTGKTTFIR | MLAGRLKPDE |
GGEVPVLNVS | YKPQKISPKS | TGSVRQLLHE | KIRDAYTHPQ | FVTDVMKPLQ |
IENIIDQEVQ | TLSGGELQRV | ALALCLGKPA | DVYLIDEPSA | YLDSEQRLMA |
ARVVKRFILH | AKKTAFVVEH | DFIMATYLAD | RVIVFDGVPS | KNTVANSPQT |
LLAGMNKFLS | QLEITFRRDP | NNYRPRINKL | NSIKDVEQKK | SGNYFFLDD
"Cloning and characterization of a RNAse L inhibitor. A new component of the interferon-regulated 2-5A pathway."
"Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects."
"RNASEL and RNASEL-inhibitor variation and prostate cancer risk in Afro-Caribbeans."
"Basic residues in the nucleocapsid domain of Gag are required for interaction of HIV-1 gag with ABCE1 (HP68), a cellular protein important for HIV-1 capsid assembly."
"ABCE1, a member of ATP-binding cassette transporter gene, encodes peptides capable of inducing HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes in colon cancer patients."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"Conservation of a stepwise, energy-sensitive pathway involving HP68 for assembly of primate lentivirus capsids in cells."
"Identification of a host protein essential for assembly of immature HIV-1 capsids."
"The 2-5A/RNase L/RNase L inhibitor (RLI) [correction of (RNI)] pathway regulates mitochondrial mRNAs stability in interferon alpha-treated H9 cells."
"RNase L inhibitor is induced during human immunodeficiency virus type 1 infection and down regulates the 2-5A/RNase L pathway in human T cells."
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